Donation after circulatory death (DCD) is a promising solution to the critical shortage of donor graft tissue. Maintaining organ viability after donation until transplantation is essential for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in clinical practice. However, ischemic damage present in DCD grafts jeopardizes organ viabil...

Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using vario...

OBJECTIVE To study attitudes, knowledge, and actions of local medical students with regard to organ donation and self-perceived confidence and competence in approaching potential organ donors. DESIGN Cross-sectional questionnaire survey. SETTING Faculty of Medicine, The University of Hong Kong, Hong Kong. PARTICIPANTS Medical students, years 1-5. MAIN OUTCOME MEASURES Knowledge on vario...

Background Nowadays, several solutions have been proposed for the minimization of both organ shortage and prolonged waiting times: the expansion of the donor pool using aged donors represents a possible solution [1]. However, it is not completely clear if the use of “extreme” donors could cause unacceptable post-transplant adjunctive risks [2]. Starting from these grounds, the aim of this study...

DUE TO SHORTAGE of organ donation, limited manpower, and financial resources, a high mortality rate was found on the waiting list for pediatric liver transplantation. The purpose of this study was to document the variable changes in the hemodynamics of hepatic artery and portal vein by Doppler ultrasound and to assess their significance to the mortality in the waiting list and the need for earl...

Over the course of the last century, organ transplantation has overcome major technical limitations to become the success it is today. The breakthroughs include developing techniques for vascular anastomoses, managing the immune response (initially by avoiding it with the use of identical twins and subsequently controlling it with chemical immunosuppressants), and devising preservation solution...

Major technical and pharmacological advances mean that lung transplantation now oVers a realistic opportunity for long term survival in selected patients with end stage pulmonary disease. 1 2 Unfortunately up to 50% of patients identified as suitable candidates to undergo lung transplan-tation will die from their underlying lung disease before an organ becomes available. 3 4 The severe shortage...

Organ printing offers a great potential for the fabrication of three-dimensional (3D) living organs by precisely layer-by-layer placing various tissue spheroids. Such fabricated organs may replace some damaged or injured human organs, emerging as a promising solution to the problem of organ donor shortage. As one of the key enabling technologies for organ printing, inkjetting has been received ...

Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the sho...

Organ donation and transplant rates vary widely across the globe, with the gap between requirements and available organs continuing to be a significant problem in many countries. This ongoing shortage has driven the creation of numerous initiatives to educate the public of the need for organ donation and to attempt to dispel urban and religious concerns over the ethics and appropriateness of or...