Significant shear localization, observed as substantial concentration gradients, is discovered in large amplitude oscillatory (LAOS) simulations of a complex fluid planar Couette setup. The localization demonstrated to occur due the inertial effects imposed by LAOS, which serve perturbations nonlinear equations describing structural response shear. Additionally, criterion for onset this present...

The effect of small-amplitude periodic shear on annealing a band in binary glasses is investigated using molecular dynamics simulations. first introduced stable via large-amplitude shear, and then amorphous samples are subjected to repeated loading during thousands cycles at strain amplitudes below the yield strain. It was found that with increasing amplitude, relocated deeper potential energy ...

Objective: This study was designed to identify hemodynamic features of aneurysms prior to rupture in comparison with unruptured aneurysms. Materials and Methods: A retrospective data of four large unruptured aneurysms (pre-ruptured group) with sufficient films just pre-rupture was used. Matched with the same location and similar sizes, another four unruptured aneurysms (unruptured group) were i...

BACKGROUND Previous clinical studies have observed relationships between increased intima-media thickness (IMT) in the carotid artery, elevated blood pressure, and low wall shear stress (WSS) calculated from the Poiseuille equation. This study used numerical methods to more accurately determine WSS in the carotid artery and to investigate possible determinants of increased IMT. METHODS IMT [c...

RATIONALE GTP cyclohydrolase I (GTPCH-1) is the rate-limiting enzyme involved in de novo biosynthesis of tetrahydrobiopterin (BH(4)), an essential cofactor for NO synthases and aromatic amino acid hydroxylases. GTPCH-1 undergoes negative feedback regulation by its end-product BH(4) via interaction with the GTP cyclohydrolase feedback regulatory protein (GFRP). Such a negative feedback mechanism...

In our previous work, we explored the dynamics of a dilute suspension of rigid dumbbells as a model for polymeric liquids in large-amplitude oscillatory shear flow, a flow experiment that has gained a significant following in recent years. We chose rigid dumbbells since these are the simplest molecular model to give higher harmonics in the components of the stress response. We derived the expre...