OBJECTIVE To investigate the effect of timing of dexamethasone administration on auditory hair cell survival following an ototoxic insult with kanamycin and furosemide. STUDY DESIGN Controlled experimental study. SETTING Translational science experimental laboratory. METHODS 5-6 week old CBA/CaJ mice, divided into 6 groups, were injected with kanamycin (1 mg/g SC) followed by furosemide (...

OBJECTIVES (1) To evaluate the ototoxic potential of docusate sodium and mineral oil and (2) to compare the cerumenolytic properties of these agents to water and a commercially available product. STUDY DESIGN Prospective animal study. SETTING Docusate sodium and mineral oil are being used to dissolve cerumen plugs. Their ototoxicity has never been assessed. METHODS Nineteen guinea pigs re...

Introduction Unilateral labyrinthectomy and intra-tympanic gentamycin have been employed in the treatment of Ménière's disease, but the efficacy of these techniques has not been well established. Objective The objective of this study is to measure the time course of recovery from a unilateral labyrinthectomy either after ipsilateral topical treatment with gentamicin to the inner ear or without ...

Chemotherapy is often used in the conservative management of retinoblastoma. Chemotherapy drugs, while ameliorative, can produce long-lasting side effects that potentially can affect survivor quality of life. Carboplatin is a common chemotherapy agent with known ototoxic side effects that is used in the treatment of retinoblastoma (RodriguezGalindo et al., 2003). The potential for carboplatin-i...

Mercury is neurotoxic, and numerous studies have confirmed its ototoxic effect. However, the diagnosis and follow-up of mercury exposure require understanding the pathophysiology of the chemical substance. Based on a systematic literature review, this study aimed to demonstrate whether mercury is ototoxic and to analyze its mechanism of action on the peripheral and central auditory system, in o...