Alluvial aquifers in mountainous regions cover typically a limited area. Their contribution to catchment storage and outflow is rarely isolated; alluvial groundwater discharge under gauging stations is generally assumed negligible; and hydrological models tend to lump alluvial storage with other units. The role of alluvial aquifers remains therefore unclear: can they contribute significantly to...

Computational fluid dynamics (CFD) modeling of the pulmonary vasculature has the potential to reveal continuum metrics associated with the hemodynamic stress acting on the vascular endothelium. It is widely accepted that the endothelium responds to flow-induced stress by releasing vasoactive substances that can dilate and constrict blood vessels locally. The objectives of this study are to exam...

OBJECTIVE To evaluate the relationship between frontal sinusitis and the localization of the frontal sinus outflow tract medial or lateral to the superior attachment of the uncinate process (UP). DESIGN A retrospective anatomical and clinical study. SETTING An ear, nose, and throat clinic in işli Etfal Teaching and Research Hospital, Istanbul, Turkey. PATIENTS Paranasal sinus computed tom...

We investigate models of self-consistent chemical enrichment of the intergalactic medium (IGM) from z = 6.0 → 1.5, based on hydrodynamic simulations of structure formation that explicitly incorporate outflows from star forming galaxies. Our main result is that outflow parameterizations derived from observations of local starburst galaxies, in particular momentum-driven wind scenarios, provide t...

The effects of bimatoprost on aqueous humor dynamics were quantified in monkey eyes. Uveoscleral outflow was measured by the anterior chamber perfusion method, using FITC-dextran. Total outflow facility was determined by the two-level constant pressure method. Aqueous flow was measured with a scanning ocular fluorophotometer. Uveoscleral outflow was 0.96 +/- 0.19 muL min(-1) in vehicle-treated ...

AIMS This study investigated the clinical and physiological significance of the dynamic left ventricle outflow gradient observed in some patients during dobutamine stress echocardiography. METHODS Three hundred and ninety-four consecutive patients completed dobutamine stress echocardiography using Doppler echocardiography to assess the presence of myocardial ischaemia and left ventricular out...

PURPOSE To test the hypothesis that extracellular matrix turnover, mediated by the matrix metalloproteinases, modulates aqueous humor outflow facility in a human outflow model. METHODS Matrix metalloproteinase activity was manipulated and outflow facility evaluated using perfused human anterior segment organ culture. Purified matrix metalloproteinases, tissue inhibitors of metalloproteinases ...

A technique for measuring resistance to outflow in enucleated eyes is described. The technique minimizes the artifactual effects of ocular stretching and anterior chamber deepening. Using this perfusion technique, it was found that the resistance to outflow in normal, enucleated human eyes increases directly and linearly with intraocular pressure. This phenomenon, termed the outflow obstruct...

The clinical and haemodynamic findings in a patient with hypertrophic obstructive cardiomyopathy and severe left ventricular outflow obstruction are presented. Treatment with an increasing dose of orally administered practolol up to a maximum of 1200 mg a day, resulted in symptomatic improvement, and abolition of the resting gradient when the patient was recatheterized six months later.