In women, around 10% of cancers occur in those younger than 45 years old. Although aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure more than 90% of girls and young women affected by disorders requiring such treatment, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Therefore, these treatments can result in premature ovarian failu...

background: ovarian cancer is the most common cause of cancer death worldwide. incidence of ovarian cancer is more common in postmenopausal women. premenopausal onset is rare and the present study described two cases of ovarian clear cell tumors in young women. case presentation: the patients presented with pelvic mass which was confirmed by sonography and laparotomy and final diagnosis was mad...

background: the interaction between follicular cells and oocyte leads to a change in gene expression involved in oocyte maturation processes. objective: the purpose of this study was to quantify the expression of more common genes involved in follicular growth and oocyte developmental competence. materials and methods: in this experimental study, the expression of genes was evaluated with qrt-p...

background: breast cancer is the most common malignancy in women. breast cancer type 1 susceptibility gene (brca1) is a tumor suppressor gene, involved in dna damage repair and in 81% of the breast-ovarian cancer families were due to brca1. in some clinically investigated genes, the intragenic marker polymorphism is important and the screening of such mutations is faster by using short tandem r...

a 52-year-old post-menopausal female was admitted to the emergency room due to acute onset of abdominal pain in the right lower quadrant. there was no history of trauma of the abdomen. contrast-enhanced multi-detector computed tomography (mdct) of the abdomen and pelvis revealed a massive right retroperitoneal hematoma and contrast extravasation from a right ovarian artery aneurysm. digital sub...

polycystic ovarian syndrome is a hetrogenous condition with a broad clinical and pathologic spectrum that may reflect the effects of diverse etiologic factors. polycystic ovarian syndrome is an abnormality in the maturation of the follicles which can result in abnormal composition of follicular fluid. by analysis and comparison of the biochemical composition of human follicular fluid in normal ...

background: to investigate the frequency of different types of gynecological tumors among patients who were operated in shahid sadoughi hospital, yazd, iran, for 3 years. material and methods: this study investigated 101 patients with gynecological tumors from march 21.2008 to march 20 2011.. lesions were considered in 5 groups according to the prevalence of malignancy. lymph node and peritonea...

objective: the goal of this study is to evaluate the efficacy of intraperitoneal (jp) cisplatin as consolidation treatment, in epithelial ovarian cancer patients with pathologically negative surgical reassessment, following first-line platinum-based chemotherapy. methods: this study included 22 patients with figo stage (iic- iv) epithelial ovarian cancer (eoc) which had no evidence of disease a...

forty ewes (3-6 years of age, average weight 41.2 kg)were randomly chosen from the flock of the sheep experiment station of tripoli university. ewes were divided into two groups, control group (c) received untreated barley straw and treatment group (t) received barley straw treated with 10% urea solution applied as 40% (v/w). barley straw was sprayed with molasses when fed to animals. both grou...

Infertility is a main manifestation of endometriosis, though the exact pathogenesis endometriosis-associated infertility remains unclear. Compromised ovarian functions may be one causes endometriosis related infertility. The function can classified into three basic elements, (1) production hormones, (2) maintenance follicular development until ovulation, and (3) reservoir dormant oocytes (ovari...