BACKGROUND The recent identification of the cold-menthol sensory receptor (TRPM8; CMR1), provides us with an opportunity to advance our understanding of its role in the pathophysiology of bladder dysfunction, and its potential mediation of the bladder cooling reflex. In this study, we report the distribution of the cool and menthol receptor TRPM8 in the urinary bladder in patients with overacti...

Overactive bladder (OAB) is a common, costly, and treatable condition in older persons. There is a wide array of available antimuscarinics for the treatment of these conditions; however, their side effect profile and the limited number of studies that evaluate their effect in the elderly curb their use. This review article focuses on OAB and its treatment, with special attention to the use of a...

• Objective: To review the diagnosis and treatment of overactive bladder (OAB). • Methods: Qualitative assessment of the literature. • Results: OAB syndrome is a highly prevalent disorder that remains vastly underreported. Typical symptoms include urinary frequency, urinary urgency, and urinary urge incontinence. Symptoms can be disruptive and impair quality of life. Behavioral therapy is the c...

Overactive bladder (OAB) syndrome occurs when the bladder contracts suddenly without the individual’s control or when the bladder is not full. Symptoms of OAB include a sudden urgent desire to pass urine (urgency), going to the toilet often (frequency), waking up to use the toilet more than once at night (nocturia), and the passing of small quantities of urine before a toilet can be reached whe...

This document reflects emerging clinical and scientific advances on the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Local institutions can dictate amendments to these opinions. They should be well documented if modified at the local level. None of these contents may be reproduced in any ...

After reading this article on overac­ tive bladder, the family physician will be able to: 1. Characterize the impact of overactive bladder in women 2. Describe the role of patient education, behavioral modification, and pharma­ cologic treatment 3. Select antimuscarinic therapy based on patient characteristics and comorbidities 4. Describe the efficacy and safety of mira­ begron and onabotulinu...

BK large conductance voltage- and calcium-activated potassium channels respond to elevations in intracellular calcium and membrane potential depolarization, braking excitability of smooth muscle. BK channels are thought to have a particularly prominent role in urinary bladder smooth muscle function and therefore are candidate targets for overactive bladder therapy. To address the role of the BK...