ticks and tick-borne diseases, including theileriosis, constitute a major constraint to livestock production. two species, known as theileria lestoquardi and theileria ovis, are suspected to contribute to ovine theileriosis in iran. however, the epidemiological aspects of ovine theileriosis are poorly understood in this country. in a survey, designed to identify theileria species in sheep, 52 (...

ovine pulmonary adenocarcinoma (opa) is a contagious and transmissible lung cancer of sheepresembling human bronchiolo-alveolar carcinoma. in the present study, lungs of 9400 sheep slaughtered infars province, iran were examined morphopathologically. the opa was diagnosed in the lungs of 21(0.22%) out of 9400 sheep. frequency of involvement of different lobes in the affected lungs was includeda...

background: the cells of mammalian female reproductive tract have been widely used for in vitro fertilization (ivf). this study was designed to study the effects of oviductal epithelial cells (oecs) and their conditioned medium during ivf on subsequent embryonic development and the relative abundance of zygote arrest 1 (zar1) transcript in ovine zygotes. methods: the in vitro matured ovine oocy...

OBJECTIVE Mesenchymal stem/stromal cells (MSC) were recently discovered in the human endometrium. These cells possess key stem cell properties and show promising results in small animal models when used for preclinical tissue engineering studies. A small number of surface markers have been identified that enrich for MSC from bone marrow and human endometrium, including the Sushi Domain-containi...

Animal models of the bleeding disorder, hemophilia A, have been an integral component of the biopharmaceutical development process and have facilitated the development of recombinant coagulation factor VIII (fVIII) products capable of restoring median survival of persons with hemophilia A to that of the general population. However, there remain several limitations to recombinant fVIII as a biot...

Members of the Toll-like receptor (TLR) family are vital to immune function through the sensing of pathogenic agents and initiation of an appropriate immune response. More specifically, tissue and cell specific TLR expression patterns have been correlated with the ability to respond to various pathogenic challenges. Bovine sequence exists for 4 of the 10 human TLR Reference Sequences and no ovi...

Prostaglandin endoperoxide H synthases (PGHS)-1 and -2 are integral membrane proteins of the endoplasmic reticulum (ER). The luminal versus cytoplasmic orientations of several epitopes of PGHS-1 and PGHS-2 were determined by immunocytofluorescent staining of cells following treatment with membrane-selective permeants. With serum-stimulated, murine NIH/3T3 cells expressing PGHS-2, an anti-peptid...

Visna/Maedi, or ovine progressive pneumonia (OPP) as it is known in the United States, is an incurable slow-acting disease of sheep caused by persistent lentivirus infection. This disease affects multiple tissues, including those of the respiratory and central nervous systems. Our aim was to identify ovine genetic risk factors for lentivirus infection. Sixty-nine matched pairs of infected cases...

Background: Cryopreservation of in vitro matured oocytes is a useful technique because the oocytes can be used for some assisted reproductive technologies. On the other hand, the cryopreservation of oocytes is an open problem as a result of their structural sensitivity to the freezing process. The purpose of this study was to evaluate the effect of vitrification on in vitro development of vitri...

Protein misfolding, protein aggregation and disruption to cellular proteostasis are key processes in the propagation of disease and, in some progressive neurodegenerative diseases of the central nervous system, the misfolded protein can act as a self-replicating template or prion converting its normal isoform into a misfolded copy of itself. We have investigated the sheep transmissible spongifo...