The involvement of NO-signaling in ultraviolet B (UV-B) induced oxidative stress (OS) in plants is an open question. Inositol biosynthesis contributes to numerous cellular functions, including the regulation of plants tolerance to stress. This work reveals the involvement of inositol-3-phosphate synthase 1 (IPS1), a key enzyme for biosynthesis of myo-inositol and its derivatives, in the respons...

A major role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes is to catalyze the production of superoxides and other reactive oxygen species (ROS). These ROS, in turn, play a key role as messengers in cell signal transduction and cell cycling, but when they are produced in excess they can lead to oxidative stress (OS). Oxidative stress in the kidneys is now c...

conclusions increment in the number of parity can lead to decrease antioxidant defense mechanisms in multiparous women and their newborns. so, control of oxidative stress is considered to be beneficial in multiparous women. background parturition has been associated with free radicals, itself linked with poor pregnancy outcome. objectives this study aimed to investigate the relationship between...

abstract background: recent studies have suggested that oxidative stress (os) may have a contribution in the pathogenesis of endometriosis. however, the results of previous studies regarding os in endometriosis are controversial. the objective of this study was to compare the serum levels of os markers in endometriosis versus the control group. methods: this case-control study was carried out o...

BACKGROUND Prostatic oxidative stress (OS) is androgen-regulated and a key event in the development of prostate cancer (PC). Thus, reducing prostatic OS is an attractive target for PC prevention strategies. We sought to determine if the individual's prostatic OS status can be determined by examining the OS in surrogate androgen regulated tissues from the same host. METHODOLOGY/PRINCIPAL FINDI...

background : methamphetamine (ma) is an illegal amphetamine-like which stimulate the central nervous system. in recent years, ma has been widely abused worldwide. previous studies have suggested that oxidative stress (os) plays an important role in ma-induced toxicity. from this view, antioxidant therapy could be considered as a potential drug therapy in ma abusers. therefore, the objective of ...

objective: spinal cord injury (sci) causes infertility in male patients through erectile dysfunction, ejaculatory dysfunction, semen and hormone abnormalities. oxidative stress (os) is involved in poor semen quality and subsequent infertility in males with sci. the aim of this study is to examine the effects of sci on the level of testosterone hormone. materials and methods: in this experimenta...

Oxidative stress (OS) has been implicated in a wide array of diseases such as neurodegenerative disorders, autoimmune diseases, complex lifestyle diseases and cancer. OS is caused by an imbalance in production of Reactive Oxygen Species (ROS) and antioxidant defenses in the cell which results in the damage of cellular components, inactivate essential metabolic enzymes and disrupt signal transdu...

Stress ulceration is single or multiple mucosal defects with/without bleeding from the gastric mucosa during the physiologic stress. Oxidative stress (OS) is a key pathogenic factor in psychogenic stress-induced acute gastric mucosal lesion (AGML). Fermented papaya preparation (FPP) is reported to have oxygen radical scavenging activity and is effective in OS-related diseases. Here, we investig...

Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). ...