OBJECTIVE To determine the oxygen outflow delivered by seven different models of manually operated self-inflating resuscitation bags (with and without an oxygen reservoir connected), which were tested using different oxygen supply rates without manipulating the bag, by simulating their use in patients breathing spontaneously. METHODS The oxygen outflow was measured using a wall oxygen flow me...

E RYTHROPOIETIN is believed to be the prime physiologic regulator of erythropoiesis.1 It is generally assumed that erythropoietin production is chiefly controlled by the demands of tissues for oxygen relative to their oxygen supply.1 According to this hypothesis transfusion-induced polycythemia results in suppression of erythropoietin production ( and consequently of erythropoiesis ) by virtue ...

Cardiovascular responses to acute hypoxemia are in part mediated through adrenergic and chemoreceptor stimulation. In chronic hypoxemia the response to these stimuli may be blunted. Therefore, we determined whether the cardiovascular responses to acute hypoxemia superimposed on 3-4 wk of chronic hypoxemia were blunted in lambs with an experimental cardiac right-to-left shunt (combination of atr...

Oxygen supply systems may be divided into constant and variable performance systems. As the variable performance systems are widely used, it is relevant to investigate the variation in performance between devices and the influence of oxygen supply on the inspired oxygen fraction. Data were collected from 10 healthy volunteers during the use of one constant performance system and four variable p...

Developing effective therapeutic interventions for pathological conditions associated with abnormal oxygen transport to muscle fibres critically depends on the objective characterisation of capillarity. Local indices of capillary supply have the potential to identify the onset of fine-scale tissue pathologies and dysregulation. Detailed tissue geometry, such as muscle fibre size, has been incor...

It is a fundamental clinical observation that wounds do not heal in tissue that does not bleed, and they almost always heal in tissue that bleeds extensively. Continuous supply of oxygen to the tissue through microcirculation is vital for the healing process and for resistance to infection. Evaluation of tissue perfusion and oxygenation is important in all types of wound patients. Monitoring sy...

The continuous work of the heart throughout life requires a high level of supply of nutrients. Because the heart has a limited and short-lived capacity for anaerobic metabolism, the functional adequacy of the coronary circulation depends on its ability to supply sufficient oxygen to meet metabolic requirements over a wide range of ventricular activity [1]. The necessary balance between myocardi...