BACKGROUND Pneumocystis jirovecii remains an important cause of fatal pneumonia (Pneumocystis pneumonia or PcP) in HIV+ patients and other immunocompromised hosts. Despite many previous attempts, a clinically useful serologic test for P. jirovecii infection has never been developed. METHODS/PRINCIPAL FINDINGS We analyzed serum antibody responses to the P. jirovecii major surface glycoprotein ...

Leukemia is the most common malignancy in children which leads to immunosuppression and predisposes patients to opportunistic infections. We report a 12-year-old girl with acute lymphoblastic leukemia (ALL) who developed simultaneous infection with pneumocystis Jirovecii pneumonia and aspergillosis in the induction phase of chemotherapy. The patient developed pulmonary cavitation and pneumothor...

BACKGROUND Little is known about the serologic responses to Pneumocystis jirovecii major surface glycoprotein (Msg) antigen in African cohorts, or the IgM responses to Msg in HIV-positive and HIV-negative persons with respiratory symptoms. METHODS We conducted a prospective study of 550 patients, both HIV-positive (n = 467) and HIV-negative (n = 83), hospitalized with cough ≥2 weeks in Kampal...

A 50-year-old male visited the outpatient clinic and complained of fever, poor oral intake, and weight loss. A chest X-ray demonstrated streaky and fibrotic lesions in both lungs, and chest CT revealed multifocal peribronchial patchy ground-glass opacities with septated cystic lesions in both lungs. Cell counts in the bronchoalveolar lavage fluid revealed lymphocyte-dominant leukocytosis, and f...

36 Microbial pathogens commonly escape the human immune system by varying surface proteins. 37 We investigated the mechanisms used for that purpose by Pneumocystis jirovecii. This 38 uncultivable fungus is an obligate pulmonary pathogen which causes pneumonia in immuno39 compromised individuals, a major life-threatening infection. Long-read PacBio sequencing was 40 used to assemble a core of su...

Microbial pathogens commonly escape the human immune system by varying surface proteins. We investigated the mechanisms used for that purpose by Pneumocystis jirovecii This uncultivable fungus is an obligate pulmonary pathogen that in immunocompromised individuals causes pneumonia, a major life-threatening infection. Long-read PacBio sequencing was used to assemble a core of subtelomeres of a s...

Non-cryptogenic organising pneumonia (OP) secondary to a Pneumocystis jirovecii infection is a rare condition described in HIV (human immunodeficiency virus) infection, lung and liver transplantation; in this brief report we discuss the first clinical case in a patient not severely immunocompromised. He was a 63 year-old man who consulted our centre’s Emergency Department referring a 2 month lo...

BACKGROUND Spontaneous resolution of Pneumocystis jirovecii pneumonia has rarely been reported. CASE REPORT A 59-year-old man presented to our hospital because of pyrexia (38°C) and shaking chills for 2 days. He had a history of right nephrectomy due to renal cell carcinoma and left upper lobectomy for lung metastasis in the last 1.5 years. Two months previously, he was treated with oral pred...

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial membrane inflammation and joint cartilage destruction. Abatacept is a biologic agent that blocks the costimulation signals, preventing antigen presentation and proliferation of T lymphocytes. It is approved for the treatment of patients with RA. Pneumocystis jirovecii pneumonia (PJP) is an infectious disease complicati...

An 88yearold woman with rheumatoid arthritis (RA) was transferred to our hospital due to cough, fever, and hypoxia. She had received 8 mg of weekly methotrexate and 4 mg of daily prednisolone and had not been given Pneumocystis jirovecii pneumonia (PCP) prophylaxis. Her chest Xray showed consolidation of the left lower lung field (Figure 1), and chest computed tomography confirmed left lower lo...