Mast cells are activated by specific allergens and also by various nonspecific stimuli, which might induce physical urticaria. This study investigated the functional expression of temperature sensitive transient receptor potential vanilloid (TRPV) subfamily in the human mast cell line (HMC-1) using whole-cell patch clamp techniques. The temperature of perfusate was raised from room temperature ...

In addition to the traditional renin-angiotensin system, a great deal of evidence favors the existence of numerous independent tissue-specific renin-angiotensin systems. We report that mast cells are an additional source of renin and constitute a unique extrarenal renin-angiotensin system. We use renin-specific antibodies to demonstrate that cardiac mast cells contain renin. Extending this obse...

We present the results of an extensive infrared study of the massive star– forming region G9.62+0.19. The data cover information from broad– and narrow–band filters in the wavelength range from 1 to 19 μm and are obtained with ESO’s near– and thermal infrared camera ISAAC at the VLT and with the mid–infrared cameras TIMMI2 (La Silla, ESO) and SpectroCam-10 (Mt. Palomar). The high sensitivity an...

Hamiltonian Monte Carlo (HMC) is a powerful tool for Bayesian computation. In comparison with the traditional Metropolis–Hastings algorithm, HMC offers greater computational efficiency, especially in higher dimensional or more complex modeling situations. To most statisticians, however, idea of comes from less familiar origin, one that based on theory classical mechanics. Its implementation, ei...

This paper develops a hybrid model combining a Hidden Markov Chain (HMC) and Multilayer Perceptrons (MLP) on the Waveletheterogeneous Index of Market Shocks (WhIMS) to identify dynamically regimes in financial turbulences. The WhIMS is an aggregate measure of volatility computed at different frequencies. We estimate the model based on a French market stock index (CAC40 Index) and compare the pr...

Hydroxyurea is an effective com[»undin inhibiting the growth of a transplantable mammary tumor (HMC) in the Fischer rat, the inhibition being dose related and independent of the duration of treatment. Several compounds related to hydroxyurea were tested and compared to the parent compound. 1-Ethyl-lhydroxy urea and 1-methyl-l-hydroxyurea are more effective than hydroxyurea in causing inhibitio...

Methylation at 5-cytosine (5-mC) is a fundamental epigenetic DNA modification associated recently with cardiac disease. In contrast, the role of 5-hydroxymethylcytosine (5-hmC)-5-mC's oxidation product-in cardiac biology and disease is unknown. Here we assess the hydroxymethylome in embryonic, neonatal, adult and hypertrophic mouse cardiomyocytes, showing that dynamic modulation of hydroxymethy...

This paper introduces a novel way of adapting the Hybrid Monte Carlo (HMC) algorithm using parametric bandits with nonlinear features. HMC is a powerful Markov chain Monte Carlo (MCMC) method, but it requires careful tuning of its hyper-parameters. We propose a Bayesian parametric bandit approach to carry out the adaptation of the hyper-parameters while the Markov chain progresses. We also intr...

We investigate numerical integration of ordinary differential equations (ODEs) for Hamiltonian Monte Carlo (HMC). High-quality integration is crucial for designing efficient and effective proposals for HMC. While the standard method is leapfrog (Störmer-Verlet) integration, we propose the use of an exponential integrator, which is robust to stiff ODEs with highly-oscillatory components. This os...

In this paper, we develop the self-learning Monte-Carlo (SLMC) algorithm for non-Abelian gauge theory with dynamical fermions in four dimensions to resolve autocorrelation problem lattice QCD. We perform simulations staggered and plaquette action by both hybrid (HMC) SLMC zero finite temperature examine validity of SLMC. confirm that can reduce time reproduce results from HMC. For runs, reprodu...