Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer's disease, type 2 diabetes, rheumatoid arthritis, and myeloma. The distribution and extent of amyloid deposition in body organs establishes the prognosis and can define treatment options; therefore, determining the amyloid load by using non-invasive molecular imaging is clinically important. We have ...

A graph is called t-perfect if its stable set polytope is fully described by non-negativity, edge and odd-cycle constraints. We characterise nearbipartite t-perfect and P5-free t-perfect graphs in terms of forbidden tminors. Moreover, we show that P5-free t-perfect graphs can always be coloured with three colours, and that they can be recognised in polynomial time.

1. The ability of myo-inositol polyphosphates to inhibit iron-catalysed hydroxyl radical formation was studied in a hypoxanthine/xanthine oxidase system [Graf, Empson and Eaton (1987) J. Biol. Chem. 262, 11647-11650]. Fe3+ present in the assay reagents supported some radical formation, and a standard assay, with 5 microM Fe3+ added, was used to investigate the specificity of compounds which cou...

Background—In the normal heart, phosphodiesterase type 5 (PDE5) hydrolyzes cGMP coupled to nitric oxide– (specifically from nitric oxide synthase 3) but not natriuretic peptide (NP)–stimulated guanylyl cyclase. PDE5 is upregulated in hypertrophied and failing hearts and is thought to contribute to their pathophysiology. Because nitric oxide signaling declines whereas NP-derived cGMP rises in su...

For the first time a dual pathway for dephosphorylation of myo-inositol hexakisphosphate by a histidine acid phytase was established. The phytate-degrading enzyme of Klebsiella terrigena degrades myo-inositol hexakisphosphate by stepwise dephosphorylation, preferably via D-Ins(1,2,4,5,6)P5, D-Ins(1,2,5,6)P4, D-Ins(1,2,6)P3, D-Ins(1,2)P2 and alternatively via D-Ins(1,2,4,5,6)P5, Ins(2,4,5,6)P4, ...

A graph is called t-perfect if its stable set polytope is fully described by non-negativity, edge and odd-cycle constraints. We characterise P5-free t-perfect graphs in terms of forbidden t-minors. Moreover, we show that P5-free t-perfect graphs can always be coloured with three colours, and that they can be recognised in polynomial time.

A graph is k-choosable if it admits a proper coloring of its vertices for every assignment of k (possibly different) allowed colors to choose from for each vertex. It is NP-hard to decide whether a given graph is k-choosable for k ≥ 3, and this problem is considered strictly harder than the k-coloring problem. Only few positive results are known on input graphs with a given structure. Here, we ...

BACKGROUND In the normal heart, phosphodiesterase type 5 (PDE5) hydrolyzes cGMP coupled to nitric oxide- (specifically from nitric oxide synthase 3) but not natriuretic peptide (NP)-stimulated guanylyl cyclase. PDE5 is upregulated in hypertrophied and failing hearts and is thought to contribute to their pathophysiology. Because nitric oxide signaling declines whereas NP-derived cGMP rises in su...

OBJECTIVE Many studies have focused on the epigenetic characteristics of donor cells to improve somatic cell nuclear transfer (SCNT). We hypothesized that the epigenetic status and chromatin structure of undifferentiated bovine adipose tissue-derived stem cells (BADSCs) would not remain constant during different passages. The objective of this study was to determine the mRNA expression patterns...

A study by Keam et al demonstrated that influenza vaccination, regardless of timing during 3-week cytotoxic chemotherapy cycles, may provide seroprotection. The majority of patients in this study were women with either breast or lung cancer. In an earlier study of patients with colorectal cancer, influenza vaccination was found to result in fewer cases of influenza, fewer cases of pneumonia, an...