Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of β-endorphin (βEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. Methods: Male Wistar rats (2...

  The present study was carried out to explore the possible involvement of the arcuate nucleus of the hypothalamus in the inhibitory descending pain control system associated with the tail flick test and EEG recordings. Adult male (NMRI) albino rats weighing 200 ± 20 g were used. Rats were divided into three groups: experimental, sham and control. The arcuate nucleus was destroyed unilaterally ...

background: neuropathic pain (np) is one of the most suffering medical conditions that often fail to respond to certain pain therapy. although its exact etiology is still unknown the role of reactive oxygen species (ros) and oxidative stress were explored by many researchers. neuropathies either central or peripheral lead to painful condition as well as social and economic isolation, thus vario...

BACKGROUND Pain affects millions of people worldwide, opioid analgesics have been used for chronic painful conditions. Due to their adverse effects, safer alternatives would be beneficial. Terminalia chebula, with proven analgesic action has been evaluated in the hot air pain model for its analgesic activity. AIM To evaluate analgesic activity and safety of single oral dose of Terminalia cheb...

OBJECTIVE To evaluate the interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis in primary care. DESIGN Two physiotherapists assessed independently, and in randomized order, the severity of complaints scored on an 11-point numeric rating scale, pain-free grip strength, maximum grip strength,...

Research in animals shows that the levels of neuropathic pain expression is genetically associated with a characteristic response profile to sensory stimuli. The aim of the present investigation was to examine if pressure algometry can identify a specific pain sensitivity profile in patients with complex regional pain syndrome, Type I (reflex sympathetic dystrophy), and to distinguish complex r...

OBJECTIVE To determine whether tactile acuity is disrupted in people with knee OA and to determine whether tactile acuity, a clinical signature of primary sensory cortex representation, is related to motor imagery performance (MIP; evaluates working body schema) and pain. METHODS Experiment 1: two-point discrimination (TPD) threshold at the knee was compared between 20 participants with painf...