Clozapine is the only antipsychotic medication that has definitely shown to be effective in treating refractory schizophrenia. Clozapine is typically the medication of choice in schizophrenic patients with a partial response to treatment. When clozapine fails to elicit a full treatment response, augmentation strategies are then explored. It is important to note, however, that in treatment resis...

BACKGROUND Mitochondrial short and long-range movements are necessary to generate the energy needed for synaptic signaling and plasticity. Therefore, an effective mechanism to transport and anchor mitochondria to pre- and post-synaptic terminals is as important as functional mitochondria in neuronal firing. Mitochondrial movement range is regulated by phosphorylation of cytoskeletal and motor p...

INTRODUCTION Post hoc analyses (two single-arm studies) were conducted to determine the impact of once-monthly injection of paliperidone palmitate on functioning in adult patients with schizophrenia in the Asia-Pacific region. METHODS Study 1 enrolled hospitalized patients with acute exacerbation of schizophrenia, and study 2 enrolled patients with recently diagnosed schizophrenia unsatisfact...

This report examines relapse risk following a switch from risperidone long-acting injectable (RLAI) to another long-acting injectable antipsychotic [paliperidone palmitate (PP)] versus a switch to oral antipsychotics (APs). Truven Health's MarketScan Multistate Medicaid Database compared relapses following switches from RLAI. New user cohorts for these two groups were created on the basis of fi...

We were presented with a 26 year old male no history of epileptic seizures suffering from amotivational symptoms induced by 4-methyl methcathinone (mephedrone). He used mephedrone eleven months ago during at least five months, approximately 5g per day. The patient was initially hospitalized for 3 because first episode drug-induced psychosis, treated intramuscular paliperidone 100mg. Since, the ...

Hyperprolactinemia is a common side effect of antipsychotic treatments. Existing alternatives to resolve this problem include decreasing the antipsychotic dose or switching to a different antipsychotic agent. Nevertheless, said modifications can sometimes lead to decompensation of the patient. We report a clinical case of a female patient in whom the combined treatment of 5 mg/day of aripiprazo...