Pancreatic duct epithelium secretes a HCO(3)(-)-rich fluid by a mechanism dependent on cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane. However, the exact role of CFTR remains unclear. One possibility is that the HCO(3)(-) permeability of CFTR provides a pathway for apical HCO(3)(-) efflux during maximal secretion. We have therefore attempted to measure electro...

Acinar necrosis is the basic microscopic sign of acute necrotizing pancreatitis (ANP). Microcirculation disorder is one of the major factors in the pathogenesis and morphogenesis of ANP besides free radicals and damage of enzymatic origin. This study is dedicated to the description of microscopic changes in the pancreatic stroma in ANP, which leads to destruction of the exocrine pancreas with a...

BACKGROUND Bacterial community structures in human pancreatic and biliary tracts were evaluated. METHODS Gall bladder stones from 153 patients, 20 gall bladder walls, six common duct stones, 52 biliary stents, 21 duodenal biopsies, nine pancreatic duct biopsies, and five bile ducts were investigated using fluorescence in situ hybridisation (FISH) with ribosomal RNA targeted Cy3/Cy5 (carbocyan...

Pancreatic carcinomas can be induced in rat, guinea pig and hamster by a variety of carcinogens. The types of neoplasms which arise vary with the species of rodent. In the rat, they consist exclusively of acinar cells, in the other species the lesions are adenocarcinomas resembling those derived from pancreatic ductules and ducts, those in hamster more so than in guinea pigs. Careful sequential...

The presence of pancreatic stem cells (PnSCs) has not been firmly demonstrated in the human or animal pancreas. Previous reports have suggested that ductal and acinar structures in the exocrine pancreas can be a potential source of progenitor cells. More recently, immature insulin precursors in the periphery of human islets have been found to self-replicate and differentiate to endocrine cells ...

BACKGROUNDS/AIMS Resection or enucleation is currently the treatment of choice for small pancreatic neuroendocrine tumors (NETs). Irreversible electroporation is a novel ablative method that is used for locally advanced pancreatic adenocarcinoma, but little data exists for its use for pancreatic NETs. We report an early experience of IRE for early pancreatic NETs. METHODS Between April 2014 a...

Autoimmune pancreatitis (AIP) is a newly recognized entity of pancreatitis that can mimic malignancy (6). Patients with AIP and pancreatic cancer have many clinical features in common, such as a higher prevalence among elderly males, frequent presentation with painless jaundice, development of diabetes mellitus, and elevated levels of serum tumor markers. Radiologically, focal swelling of the p...

Clonorchis sinensis is one of the most common causes of trematodiasis that is caused by the ingestion of raw fish contaminated with infective cysts. The adult flukes are predominantly present in the intrahepatic bile ducts, but occasionally they may be found in the pancreatic duct and extrahepatic bile ducts. The clinical manifestations depend on the number of flukes, the period of infestation,...

Context Intraductal papillary mucinous neoplasms of the pancreas can be associated with ordinary ductal adenocarcinomas as well as pancreatic intraepithelial neoplasias in the background pancreas; however, preoperative identification of peripheral pancreatic intraepithelial neoplasias is extremely difficult. Case report The patient was a 79-year-old male with a chief complaint of right hypochon...

Newer laboratory aids complement evaluation of a patient with suspect pancreatic tumor, pancreatic adenocarcinoma, pseudocyst of the pancreas and islet cell adenoma. Hypertonic duodenography, artériographie study of the celiac trunk and superior mesenteric tree when combined may yield invaluable diagnostic information in patients with ampullary carcinoma. The new tech­ niques of transduodenal v...