Chronic pancreatitis is an inflammatory disease characterized by the progressive destruction of pancreatic tissue and resulting in pancreatic exocrine and endocrine insufficiency. Although a lot of efforts have been made in managing chronic pancreatitis, treatment of chronic pancreatitis is still challenging and remains mostly empirical. Medical treatment of chronic pancreatitis focuses on chro...

The pancreatic processing enzymes, PC1 and PC2, convert proinsulin to insulin and convert proglucagon to glucagon and glucagon-like peptide 1 (GLP-1). We examined the effect of streptozotocin (STZ) treatment on the regulation of these enzymes and the production of insulin, glucagon, and GLP-1 in the rat. Pancreatic PC1 and PC2 mRNA increased >2-fold and >4-fold, respectively, in rats receiving ...

OBJECTIVE To measure activities of digestive enzymes during postnatal development in dogs. SAMPLE POPULATION Gastrointestinal tract tissues obtained from 110 Beagles ranging from neonatal to adult dogs. PROCEDURE Pepsin and lipase activities were measured in gastric contents, and amylase, lipase, trypsin, and chymotrypsin activities were measured in small intestinal contents and pancreatic ...

An unusual case of bilateral ureteric obstruction and hydronephrosis due to pancreatic pseudocyst formation, after an episode of acute pancreatitis is reported. All abnormalities resolved with conservative management. Possible reasons for such ureteric obstruction include periureteric fat necrosis by pancreatic enzymes and compression by the inflammatory mass.

CONTEXT This is the first report associating heterotopic pancreas in the gallbladder and elevated pancreatic enzymes in bile. CASE REPORT A 60-year-old woman underwent abdominal ultrasonography at a medical check-up, revealing a nodular protrusion at the neck of the gallbladder. It seemed likely to be a lymph node, but we could not exclude the possibility of gallbladder cancer. In order to ma...

known as Bai Feng Wan) is a well-known traditional Chinese medicine widely used for treating gynecnological disorders. It has also been used to treat hepatitis, for improvement of immunological function, blood circulation and overall body functions. We have recently reported that BFP ethanol extract exerted a stimulatory effect on gastrointestinal Cl secretion, indicating possible beneficial ef...

Pancreas secretes fluid rich in digestive enzymes and bicarbonate. The alkaline secretion is important in buffering of acid chyme entering duodenum and for activation of enzymes. This secretion is formed in pancreatic ducts, and studies to date show that plasma membranes of duct epithelium express H(+)/HCO(3)(-) transporters, which depend on gradients created by the Na(+)/K(+)-ATPase. However, ...

The pathogenesis of alcoholic pancreatitis is not fully understood. An increase in pancreatic digestive and lysosomal enzyme synthesis because of ethanol consumption could contribute to the development of pancreatic injury in alcoholics. This study aimed, firstly, to determine the effect of ethanol on the content and messenger RNA levels of pancreatic digestive enzymes and on the messenger RNA ...

In human body, we have two essential fatty acids such as linoleic acid and arachidonic acid which are playing an important role in the development and progression of pancreatic cancer. Both of these fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Extensive scientific studies show that abnormal expression and activities of both cyclooxygenases and lipoxygenases a...

During the period of morphogenesis of the rat pancreas, the specific exocrine enzymes accumulation pattern from Day 13 through Day 14 to as late as Day 15 is a low and constant basal level of each specific protein (the protodifferentiated level). Subsequently, the levels of the exocrine enzymes increase dramatically. The specific activities of chymotrypsin(ogen), trypsin(ogen), (pro)carboxypept...