OBJECTIVES To identify consumer information needs about paracetamol, the most commonly used analgesic and antipyretic worldwide. DESIGN Retrospective analysis of medicines questions from the public. SETTING Australian consumer medicines call centre. PARTICIPANTS Callers to National Prescribing Service Medicines Line between September 2002 and June 2010 (n=123 217). MAIN OUTCOME MEASURES...

The numbers of deaths from paracetamol poisoning have risen steadily in England and Wales since the first cases of fulminant hepatic failure caused by paracetamol poisoning were reported in 1966.'-3 In 1984 there were 176 deaths from paracetamol alone and a further 305 from paracetamol with other drugs, notably dextropropoxyphene.4 Adults account for most of the serious and fatal cases; young c...

BACKGROUND There has been a trend over recent years for combining a nonsteroidal antiinflammatory drug (NSAID) with paracetamol (acetaminophen) for pain management. However, therapeutic superiority of the combination of paracetamol and an NSAID over either drug alone remains controversial. We evaluated the efficacy of the combination of paracetamol and an NSAID versus either drug alone in vario...

OBJECTIVE To evaluate the effects on suicidal behaviour of legislation limiting the size of packs of paracetamol and salicylates sold over the counter. DESIGN Before and after study. SETTING UK population, with detailed monitoring of data from five liver units and seven general hospitals, between September 1996 and September 1999. SUBJECTS People who died by suicidal or accidental overdos...

Previously, prior approval from the on-call chemical pathologist was required in our hospital for plasma paracetamol measurements. However, since May 1992, there have been no restrictions on ordering this assay. We have assessed the consequences of this policy change by comparing the number and appropriateness of requests for plasma paracetamol measurements in Chinese patients admitted to our h...

STUDY OBJECTIVE We investigate the efficacy and safety of oral paracetamol compared with oral nonsteroidal antiinflammatory drugs or combination therapy in relieving pain after blunt limb injury in an emergency department (ED). METHODS This was a double-blind, randomized, controlled study in an ED of a university hospital in the New Territories of Hong Kong. Three hundred adult patients with ...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...

Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromboxane, nitric oxide (NO), and oxidative stress in four male subjects who recei...

introduction: optimum pain management immediately after surgeries can lower the possibility of pain syndrome and its following consequences. opioids are amongst the analgesics used for postoperative pain control; however, their application can bring about several adverse effects. in this study, all the published articles regarding efficacy of paracetamol   in post-cardiac surgery pain managemen...

OBJECTIVE To compare the effect of different reaction temperatures on the cyclization and coupling reactions of the Toruzyme CGTase influencing the yield of cyclodextrins (CDs) and to study the solubility of paracetamol with CDs. MATERIAL AND METHOD Type and amount of CDs were analyzed by HPAEC-PAD. The stability constants for the inclusion complex formed between CDs and paracetamol were dete...