軟骨の研究は,骨 代謝研究のなかでも発生生物学的な アプロー チの視点から急速に進歩 してきた領域の1つ で ある。軟骨細胞の分化増殖,さ らに軟骨内骨化に対する 調節因子の研究は,基 礎的な細胞生物学ばか りでなく先 天異常を含めた遺伝子疾患の解明にも及び,そ の必要性 が再認識 されている(図1)。 そのなかで副甲状腺ホルモ ン関連ペ プチ ド(parathyroid hormone-related peptide: PTHrP)は,軟 骨の分化増殖に最 も重要な因子で あり,多 くの研究者によってその詳細が明 らかにされて いる。PTHrPに ついては,す でに1950年 代 にAlbright が,悪 性腫瘍から産生される副甲状腺ホルモン(PTH) 様の物質でありhumoral hypercalcemia of malignancy の高カルシウム血症の起因物質 としてその存...

V a r i o u s imaging methods have been used for the preoperative localization of parathyroid tumors in patients with hyperparathyroidism. Among the noninvasive methods, several scintigraphic techniques have been employed, including variations on the dual-isotope 2°ITI/99mTC subtraction techniques (1-3). Modification of this technique, using 123I instead of [99mTC] pertechnetate, has also been ...

Endocrine pancreatic tumors are rare neoplasms that occur sporadically or as part of a multiple endocrine neoplasia type 1 (MEN1) syndrome. Germ-line mutations of the MEN1 gene, located at 11q13, have been demonstrated in MEN1 kindreds, and loss of heterozygosity (LOH) on 11q13 together with somatic MEN1 mutations have been detected in 20% of nonfamilial parathyroid tumors. Here, we examine 11 ...

Endocrine pancreatic tumors are rare neoplasms that occur sporadi cally or as part of a multiple endocrine neoplasia type 1 (MENI) syn drome. Germ-line mutations of the MENI gene, located at Ilql3, have been demonstrated in MENI kindreds, and loss of heterozygosity (LOH) on I lt/1,1 together with somatic MENI mutations have been detected in 20% of nonfamilial parathyroid tumors. Here, we examin...

Neuroendocrine tumours belong to a heterogeneous family of neoplasms, originating in endocrine glands (such as the pituitary, parathyroid or the neuroendocrine adrenal glands), in endocrine islets (within the thyroid or pancreas) as well as in endocrine cells dispersed between exocrine cells throughout the digestive or respiratory tracts. The clinical behaviour of neuroendocrine tumours is vari...

The rare hereditary syndrome, multiple endocrine neoplasia type1 (MEN-1), is known to predispose affected individuals to endocrine neoplasms in a variety of tissues such as the parathyroid glands, the pituitary gland and the gastrointestinal tract. We describe the case of a man with traditionally-described manifestations (hyperparathyroidism and gastrinoma) and with other tumoral lesions arisin...

Background: MEN1 is a rare hereditary syndrome which manifests a variety of endocrine and non-endocrine neoplasms and lesions. Introduction: A 59 year-old male with good clinical status was referred to our hospital due to chronic episodes of diarrhea. Imaging studies revealed multiple polyps in various parts of the colon, a pancreatic tail tumor, 2 hepatic lesions, bilateral adrenal hyperplasia...

BACKGROUND The purpose of this study was to examine trends in neck dissection and regionalization. METHODS This cross-sectional and longitudinal study used the years 2000, 2004, and 2006 data from the Nationwide Inpatient Sample. Chi-square tests compared trends for total neck dissections and specific subsites. To test regionalization, we examined the distribution of procedures across hospita...

Neuroendocrine tumours (NETs) represent a heterogeneous family of neoplasms, which may develop from different endocrine glands (such as the pituitary, the parathyroid or the neuroendocrine adrenal glands), endocrine islets (within the thyroid or pancreas) as well as from endocrine cells dispersed between exocrine cells throughout the digestive and respiratory tracts. The development of somatost...

BACKGROUND Perivascular epithelioid cell tumors (PEComas), make up a family of extremely rare mesenchymal neoplasms, with characteristic morphological, immunohistochemical and molecular findings. Malignant PEComas and gastrointestinal epithelioid angiomyolipoma (E-AML) are especially rare. To the best of our knowledge E-AML have not been found in the breast. The difficulty in determining what c...