A 6-year-old boy presented with sudden onset of progressive, asymptomatic crops of well-demarcated, symmetrical, hypomelanotic macules ranging in size from 0.1 to 0.5 cm [Figures 1-3]. The eruption appeared in crops and began on the forearms and then spread to legs and thighs and face over a period of 1 week. Most lesions were non-scaly and discrete. Some closely situated macules showed conflue...

The severe acute respiratory syndrome coronavirus two (SARS-CoV-2), which causes the 2019 disease (COVID-19), has infected patients worldwide. Physicians have increasingly identified cutaneous findings as a significant clinical manifestation of COVID-19. In this review, we describe presentation, onset, duration, associated symptoms, treatment, and outcome manifestations thus far reported to be ...

COVID-19 can affect multiple organs, including skin. A wide range of skin manifestations have been reported in literature. Six main phenotypes identified: i) urticarial rash, ii) confluent erythematous/maculopapular/morbilliform iii) papulovesicular exanthem, iv) a chilblain-like acral pattern, v) livedo reticularis/racemosa-like and vi) purpuric vasculitic pattern. The pathogenetic mechanism i...

Zusammenfassung Das familiäre Mittelmeerfieber (FMF) ist die häufigste autoinflammatorische Erkrankung und gehört zu den monogenetischen Fiebersyndromen. Die beruht auf einer Mutation des MEFV -Gens; dieses dem kurzen Arm von Chromosom 16 lokalisiert kodiert für das Protein Pyrin. Pyrin aktiviert über mehrere Schritte eine erhöhte Ausschüttung der proinflammatorischen Zytokine Interleukin (IL)‑...