Cork oak (Quercus suber L.) and holm oak (Quercus rotundifolia) ecosystems are characteristic of Mediterranean forestry in Portugal. Even though cork is the most valuable product, these ecosystems provide multiple products and services. Assessing trade-offs between multiple goals is thus critical for the effectiveness of oak ecosystem management planning. This paper focuses on the development o...

The immunogenicity of biotherapeutics can bottleneck development pipelines and poses a barrier to widespread clinical application. As a result, there is a growing need for improved deimmunization technologies. We have recently described algorithms that simultaneously optimize proteins for both reduced T cell epitope content and high-level function. In silico analysis of this dual objective desi...

We consider the two-parallel machines scheduling problem, with the aim of minimizing the maximum lateness and the makespan. Formally, the problem is defined as follows. We have to schedule a set J of n jobs on two identical machines. Each job i ∈ J has a processing time pi and a delivery time qi. Each machine can only perform one job at a given time. The machines are available at time t = 0 and...

Multi objective (MO) optimization is an emerging field which is increasingly being implemented in many industries globally. In this work, the MO optimization of the extraction process of bioactive compounds from the Gardenia Jasminoides Ellis fruit was solved. Three swarm-based algorithms have been applied in conjunction with normal-boundary intersection (NBI) method to solve this MO problem. T...

Time series monitoring methods, such as the Brown and Trigg methods, have the purpose of detecting pattern breaks (or “signals”) in time series data reliably and in a timely fashion. Traditionally, researchers have used the average run length statistic (ARL) on results from generated signal occurrences in simulated time series data to calibrate and evaluate these methods, with a focus on timeli...

This paper proposes a solution to calculate the Pareto frontier for the execution of a batch of jobs versus data transfer time for hybrid clouds. Based on the nature of the cloud application, jobs are assumed to require a number of data-files from either public or private clouds. For example, gene probes can be used to identify various infection agents such as bacteria, viruses, etc. The heavy ...

W study the problem of (re)designing the regional network by which cadaveric livers are allocated. Whereas prior research focused mainly on maximizing a measure of efficiency of the network that was based on aggregate patient survival, we explicitly account for the trade-off between efficiency and a measure of geographical equity in the allocation process. To this end, we extend earlier optimiz...

In many practical investment situations the amount of available memory on stock data is extremely huge. Thus many investors are attracted to base their decisions on the information "currently available in their minds" (see [1, 2]). In the present paper various risk measurement models having application in the investment management are discussed. First we explain the concept of mean variance eff...

PURPOSE To add mathematical rigor to the merging phase of the recently published two-stage VMAT optimization method called VMERGE. Using an exact merging method, we are able to better characterize the tradeoff between delivery efficiency and dose quality. METHODS VMERGE begins with an IMRT plan that uses 180 equi-spaced beams and yields the "ideal" dose. Neighboring fluence maps are successiv...

In multiobjective optimization problems, the identified Pareto Frontiers and Sets often contain too many solutions, which make it difficult for the decision maker to select a preferred alternative. To facilitate the selection task, decision making support tools can be used in different instances of the multiobjective optimization search to introduce preferences on the objectives or to give a co...