Migration of growth cones is in part mediated by adhesive interactions between filopodia and the extracellular environment, transmitting forces and signals necessary for pathfinding. To elucidate the role of substrate adhesivity in growth cone pathfinding, we developed an in vivo assay for measuring filopodial-substrate adhesivity using the well-characterized Ti pioneer neuron pathway of the em...

3-D prestack common-azimuth depth migration has strong potential for accurately imaging complex media and correctly handling multi-pathing. Here, we apply the technique to a North Sea real data containing a salt dome. The results obtained demonstrate the suitability of the method for complex media. A detailed analysis of associated angle-domain common-image gathers shows opportunities for impro...

Existing generative mobility models, used to produce mobility data for simulated agents in, e.g., wireless network simulations, suffer from a number of limitations. Most significantly, existing models are not representative of actual human movement. We introduce a new mobility model based on state-of-the-art work in understanding pedestrian mobility patterns in urban areas, known as Space Synta...

Real-time video games are a unique domain for pathfinding and search. Traditional approaches to search have usually assumed static worlds with a single agent. But, in real-time video games there are multiple cooperative and adversarial agents. While the search space in most games is relatively small, algorithms are expected to plan in mere milliseconds. Thus, techniques such as abstraction are ...

In this paper, we present SimHuman, a platform for the generation of real-time 3D environments with virtual agents. SimHuman is highly dynamic and configurable, as it is not based on fixed scenes and models, and has an embedded physically based modelling engine. Its agents can use features such as path finding, inverse kinematics and planning to achieve their goals. The paper explains in detail...

Among the earliest events in visual system development are RGC axon pathfinding within the retina to the optic disc and subsequent axon growth through the disc into the optic stalk to form the optic nerve. Guidance mechanisms underlying these pathfinding tasks are not completely understood. Studies demonstrate that at the optic disc, the axon guidance molecule netrin-1 controls, to a large exte...

Cooperative pathfinding is a problem of finding a set of non-conflicting trajectories for a number of mobile agents. Its applications include planning for teams of mobile robots, such as autonomous aircrafts, cars, or underwater vehicles. The state-of-the-art algorithms for cooperative pathfinding for embodied robots typically rely on some heuristic forward-search pathfinding technique, where A...

Plexin receptors play a crucial role in the transduction of axonal guidance events elicited by semaphorin proteins. In Drosophila, Plexin A (PlexA) is a receptor for the transmembrane semaphorin semaphorin-1a (Sema-1a) and is required for motor and central nervous system (CNS) axon guidance in the developing embryonic nervous system. However, it remains unknown how PlexB functions during neural...