A female Holstein Friesian calf with inferior cervical ectopia cordis was followed from the 16th day of age until euthanasia at the age of three months. The heart was located in the lower cervical region and was covered with skin. The calf was presented with normal heart and respiratory rate. A grade II/VI systolic murmur was audible at the heart base when the calf was checked for the first tim...

Thyroid carcinomas are the most frequently occurring tumours in the endocrine system. Metallothioneins (MT) and Ki-67 proteins are present in intensely proliferating cells, and their expression has been observed in numerous tumours, including thyroid tumours. The purpose of this study was to analyse the relationship between intensity of MT expression and Ki-67 antigen on one hand and histologic...

Reliable animal models are required for the in vivo study of the molecular mechanisms and effects of chemotherapeutic drugs in hepatocarcinoma. In vivo tracing techniques based on firefly luciferase (FLuc) may optimize the non-invasive monitoring of experimental animals. The present study established a murine Hepa1-6-FLuc cell line that stably expressed a retrovirus-delivered FLuc protein gene....

To investigate the pathologic mechanisms of toll-like receptor 4 (TLR4) in lung injury and atherosclerosis, ApoE⁻/⁻ or wild-type mice were intraperitoneally administered saline, lipopolysaccharides (LPS), or LPS plus TAK-242 (TLR4 inhibitor), respectively, twice a week for 4 weeks. Serum autoantibody of antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA), and cytokines of interfer...

1 Purpose To study the pathomorphology of subretinal hemorrhage (SRH) seen in eyes with 2 branch retinal vein occlusion (BRVO) and its association with visual prognosis. 3 Methods We reviewed retrospectively 42 consecutive patients (42 eyes) with BRVO that 4 affected the fovea. Retinal structural changes were examined by spectral domain optical 5 coherence tomography (SD-OCT). 6 Results On SD-O...

In the last decade femoroacetabular impingement (FAI), defined as a conflict between anterior femoral head-neck junction and anterior acetabular rim, has been proposed as the beginning of early osteoarthritis of the hip and popularised with more than 200 papers published in peer-review journals. This syndrome leads lesions in the labrum and adjacent acetabular cartilage, which could result in d...

Acellular nerve allografts can help preserve normal nerve structure and extracellular matrix composition. These allografts have low immunogenicity and are more readily available than autologous nerves for the repair of long-segment peripheral nerve defects. In this study, we repaired a 40-mm ulnar nerve defect in rhesus monkeys with tissue-engineered peripheral nerve, and compared the outcome w...

BACKGROUND AND PURPOSE Our aim was to explore the changes of CSF and spinal pathomorphology after high-concentration ozone injection into a pig's subarachnoid space. MATERIALS AND METHODS Eight experimental pigs were randomly divided into 4 groups (n=2 in each group). In groups A, B, C, and D, animals were sacrificed for pathology 1 day, 1 week, 1 month, and 3 months after the injection, resp...

AIM To evaluate whether the effect of dendritic cells (DCs) on chronic obstructive pulmonary disease (COPD) can be relieved by blocking CCL20. METHODS 30 Wistar rats were randomly divided into three groups: control, COPD, and COPD treated with CCL20 monoclonal antibody. In the latter two groups, COPD was induced by four-week cigarette smoke exposure and trachea injection of lipopolysaccharide...