Objective: To investigate the effects of growth factors fibroblast-derived extracellular matrix formation in the 3D fiber-deposited polycaprolactone (PCL) scaffold fabricated by 3D printing technique for tissue engineering applications of tunica albuginea. Methods: PCL scaffold was fabricated by 3D bioprinting system. For in vitro cell study, scaffolds were seeded with human fibroblast cell at ...

INTRODUCTION Mucoid degeneration of cruciate ligament is well known entity, but symptomatic lesions are rare. It is even rarer to find a symptomatic posterior cruciate ligament mucoid degeneration than anterior cruciate ligament. CASE REPORT A 65-years-old female presented to our hospital complaining of pain in right knee joint on terminal extension since 6 months. On clinical examination, th...

The development of a new family of implantable bioinspired materials is a focal point of bone tissue engineering. Implant surfaces that better mimic the natural bone extracellular matrix, a naturally nano-composite tissue, can stimulate stem cell differentiation towards osteogenic lineages in the absence of specific chemical treatments. Herein we describe a bioactive composite nanofibrous scaff...

Mesenchymal stem cells (MSC) have been used recently for the treatment of autoimmune diseases in murine animal models due to the immunoregulatory capacity. Current utilization of MSC requires cells in certain quantity with multiple courses of administration, leading to limitation in clinical usage. Here we efficiently treated collagen-induced arthritis rats with a single local implantation with...

Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffolding. Using emergent (nano)technologies scaffold designing may be critically im...

Abstract In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, SF/PCL characterized combined techniques of scanning electron microscopy (SEM), equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) cell viability test. The results indicat...

The prevalence of osteoarthritis, a degenerative cartilage disease that causes joint surface erosion and loss mobility, emphasizes the need producing functional articular replacement. Tissue engineering has been focus recent research as possible strategy for regeneration repair. most widely used technique manufacture nanofibers is polymer electrospinning. Polylactic acid (PLA) polycaprolactone ...

We demonstrate a rice leaf-like hierarchically textured polymer fiber array for anisotropic non-wetting surfaces. To provide superhydrophobicity in addition to the anisotropic behavior, fiber surfaces are spray coated with organically modified silica nanoparticles. The resulting micro/nano hierarchically structured fiber surfaces demonstrate anisotropic non-wetting properties. We designed vario...

Aligned electrospun scaffolds are promising tools for engineering fibrous musculoskeletal tissues, as they reproduce the mechanical anisotropy of these tissues and can direct ordered neo-tissue formation. However, these scaffolds suffer from a slow cellular infiltration rate, likely due in part to their dense fiber packing. We hypothesized that cell ingress could be expedited in scaffolds by in...