Abstract Pediatric brain tumor preclinical development has suffered from the lack of robust in vitro and vivo models that span large number histologies. Opportunities for precision medicine approaches solid tumors are expanding, including immunotherapies, so it is essential to maximize access studies specificity, efficacy, safety treatments ways align patient samples their clinical course. The ...

Abstract Pediatric low-grade glioma incidence has been rising in the U.S. over last 20 years, concurrent with a rate of obesity both adult and pediatric populations. Recently, children obese mothers have demonstrated to increased rates several tumors, including brain tumors. Importantly, is driven large part by diet, given abundance accessibility high-fat, high-sugar food choices. High-fat diet...

BACKGROUND Human herpesvirus-6 (HHV-6) has been associated with a diverse spectrum of central nervous system (CNS) diseases and reported glial tropism. OBJECTIVE To determine if HHV-6 is present in a series of pediatric brain tumors. STUDY DESIGN Pediatric gliomas from 88 untreated patients represented in a tissue microarray (TMA) were screened for HHV-6 by nested polymerase chain reaction ...

BACKGROUND AND PURPOSE Gadolinium-enhanced MR images assist in defining tumor borders; however, the relation between tumor cell extent and contrast-enhanced regions is unclear. Our aim was to improve conventional neuroimaging of pediatric brain tumors with hemodynamic, diffusion, and spectroscopic MR imaging. METHODS We performed conventional MR and MR spectroscopic imaging in 31 children wit...

Introduction While leukemias are the most common type of malignancy to afflict the pediatric population, brain tumors are the most common solid tumors in this age group. Medulloblastoma is the most common malignant brain tumor in children, accounting for 20% of all pediatric brain tumors. It is categorized as a primitive neuroectodermal tumor of the cerebellum. While mortality within the first ...

introduction bnct is an effective method to destroy brain tumoral cells while sparing the healthy tissues. the recommended flux for epithermal neutrons is 109 n/cm2s, which has the most effectiveness on deep-seated tumors. in this paper, it is indicated that using d-t neutron source and optimizing of beam shaping assembly (bsa) leads to treating brain tumors in a reasonable time where all iaea ...

introduction: during radiotherapy, high accuracy in the dose delivery is required because there is a strong  relationship between the absorbed dose, local tumor control and particularly the normal tissue damage. in  many institutions, in vivo dosimetry using diodes is performed to check the actual dose delivered. in general,  the uncertainty in the dose delivered should fall within  ± 5% of the...

Compared with brain tumors in adults, a much higher percentage of pediatric brain tumors arise in the posterior fossa, which includes the brain stem and cerebellum. While astrocytoma’s can be found elsewhere in the brain, the majority are found in the posterior fossa. These infratentorial astrocytoma tumors comprise as many as two thirds of all pediatric brain tumors [1]. An astrocytoma is typi...

Atypical teratoid rhabdoid tumors (AT/RTs) are rare pediatric brain tumors characterized by bialleic loss of the SMARCB1 tumor suppressor gene. In contrast to pediatric AT/RT that has a simple genome, very little is known about the adult AT/RT genomic landscape. Using a combination of whole-exome sequencing and high-resolution SNP array in a single adult pituitary AT/RT, we identified a total o...