www.thelancet.com Published online March 6, 2017 http://dx.doi.org/10.1016/S0140-6736(17)30549-4 1 Bullous pemphigoid is the most common autoimmune blistering skin disease, and incidence is on the rise, due at least in part to its association with older age. Treatment of bullous pemphigoid presents a challenge to the clinician, as first-line treatment regimens—either oral corticosteroids or who...

Bullous pemphigoid is a rare complication of immune checkpoint inhibitor treatment. We report case pembrolizumab-induced bullous in patient with malignant melanoma and concomitant cutaneous squamous cell carcinoma that regressed. A 77-year-old woman metastatic 3-year history growing skin nodule on her left calf was treated pembrolizumab. Histopathological examination the established diagnosis c...

Azathioprine was given to 11 patients with pemphigoid who had been on long-term maintenance therapy with prednisone or prednisolone. In nine of these prednisone therapy was withdrawn and all were maintained symptom-free on azathioprine alone, while in two the dose of prednisone was considerably reduced. One patient who had never received corticosteroids was controlled by azathioprine alone duri...

Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND ...

BP: bullous pemphigoid TNF: tumor necrosis factor INTRODUCTION Bullous pemphigoid (BP) is an uncommon skin condition in which erythematous, urticarial papules and plaques progress to form tense bullae, typically in elderly men and women. In this disease, IgG autoantibodies are directed against hemidesmosome proteins, resulting in the formation of subepidermal vesicles. At least 50 drugs have be...

© 2010 The Authors. doi: 10.2340/00015555-0734 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Dyshidrosiform pemphigoid (DP) is an unusual variant of localized pemphigoid presenting with a persistent vescicobullous eruption localized to the soles or palms or both, similar to dyshidrosiform dermatitis. This condition is rarely reported in the literature, it generally ...

A 78-year-old man presented with cutaneous blisters of the limbs and abdominal distension. He had been treated for various diseases, including liver cirrhosis. He had begun receiving sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, for diabetes mellitus three years before the hospitalization. A skin biopsy demonstrated bullous pemphigoid. Ultrasonography (US) revealed multiple liver tum...