In this issue Health by Numbers explores asthma hospitalizations and emergency department (ED) visit rates in relation to Healthy People 2010 (HP2010) goals. Two HP2010 objectives for asthma are specific to hospitalizations and ED visits. Objective 24-2 sets the following targets for asthma hospitalizations by age group: (1) an age-specific rate of 25 per 10,000 children under age 5 years, (2) ...

AI systems are now or will soon be sophisticated enough to make consequential decisions. Although this technology has flourished, we also need public appraisals of AI systems playing these more important roles. This article reports surveys of preferences for and against AI systems making decisions in various domains as well as experiments that intervene on these preferences. We find that these ...

This chapter introduces a novel framework for modeling interacting humans in a multi-stage game. This “iterated semi network-form game” framework has the following desirable characteristics: (1) Bounded rational players, (2) strategic players (i.e., players account for one another’s reward functions when predicting one another’s behavior), and (3) computational tractability even on real-world s...

The evolution of opinions in a population of individuals who constantly interact with a common source of user-generated content (i.e. the internet) and are also subject to propaganda is analyzed using computer simulations. The model is based on the bounded confidence approach. In the absence of propaganda, computer simulations show that the online population as a whole is either fragmented, pol...

BACKGROUND Often, outcomes in clinical trials of antipsychotic medications are examined using last observation carried forward (LOCF). One limitation of LOCF and other common approaches is that they overlook the meaning underpinning trial completion and noncompletion. Noncompletion often relates to lack of drug tolerability. Because long-term treatment is often indicated, noncompletion is an im...

Missing data can frequently occur in a longitudinal data analysis. In the literature, many methods have been proposed to handle such an issue. Complete case (CC), mean substitution (MS), last observation carried forward (LOCF), and multiple imputation (MI) are the four most frequently used methods in practice. In a real-world data analysis, the missing data can be MCAR, MAR, or MNAR depending o...

dear editor periodontitis is an inflammatory disease that affects the supporting tissues of the teeth. it is caused by specific microorganisms and leads to progressive destruction of periodontal ligaments and alveolar bone along with pocket formation, attachment loss or both (1). generally, periodontal diseases are chronic infections caused by special groups of bacteria, have long been consider...

This study compares two methods for handling missing data in longitudinal trials: one using the last-observation-carried-forward (LOCF) method and one based on a multivariate or mixed model for repeated measurements (MMRM). Using data sets simulated to match six actual trials, I imposed several drop-out mechanisms, and compared the methods in terms of bias in the treatment difference and power ...