OBJECTIVES To develop a new method for gastric cancer detection with gastric juice using melanoma-associated gene (MAGE) RNA and pepsinogen (PG). METHODS In total, 183 gastric juice and paired serum specimens were obtained from 134 patients with gastric cancer and 49 healthy individuals. The gastric juice specimens were analyzed with MAGE A1 to A6 nested reverse transcription-polymerase chain...

: Pepsin is an aspartate protease that generated from its proenzyme, pepsinogen by autocatalysis initiated a fall in pH below 5. Human gastric juice contains eight isoenzymes of pepsin. The peptides released on conversion to pepsin which there are potentially five, have been shown antimicrobial activity against wide range bacteria including Escherichia coli, Pseudomonas and Staphylococcus also ...

The gastric cancer risk varies based on the etiology and severity of gastritis, which depends a history Helicobacter pylori infection secretory capacity stomach. Type A gastritis is associated with reverse atrophy corpus type B progressive extending from antrum to corpus. Diffuse or spotty redness in together high serum pepsinogen (PG) II levels low PG I/II ratio are observed patients H. when s...

Phenylbutazone in moderate dosage has been administered to 15 patients with a variety of musculo-skeletal disorders. A rise in plasma pepsinogen activity occurred in 13, generally reaching a peak in the first week of treatment; subsequently there was a fall in spite of maintaining a constant dosage. In four of six patients an anticholinergic drug failed to prevent a rise in plasma pepsinogen ac...

Parallel increments of gastric acid and pepsinogen secretion generally occur after the application of cholinergic stimuli. However, it still remains to be established whether the changes in acid output associated with cholinergic stimulation play a role in regulation of the concomitant peptic secretory activity. In the present study, an anesthetized rat model was used for the evaluation of peps...

Objective: This study aims to investigate the clinical significance of gastrin 17 and pepsinogen in gastric cancer and precancerous lesion screening. Methods: We used ELISA to measure the levels of gastrin 17 and pepsinogen in serum from the medical examination population, which compared to endoscopic results. Then statistical analysis was performed. Results: The classical method by testing pep...

To the Editors: as a comment to the editorial of Oderda et al: In an interesting editorial in this issue of the journal, Oderda et al (1) review which tests may be used to diagnose Helicobacter pylori (H. pylori) in children. Some are invasive (i.e. upper gastro-intestinal endoscopy and multiple gastric biopsies), and some are non invasive (i.e. serology, C-urea breath test and stool antigen de...