BACKGROUND & AIM The important role of IL-17 in inflammatory response to Helicobacter pylori (H. pylori) colonization has been indicated. We investigated the associations between gastro-duodenal diseases and polymorphisms of IL17A (rs2275913 G>A) and IL17F (rs763780 T>C). METHODS The study was performed in 548 subjects (363 controls and 185 peptic ulcer cases). The multiplex PCR-SSCP method w...

Peptic ulcer disease including both gastric and duodenal ulcer form a substantial part of patients seeking surgical opinion world-wide. The concept of acid in peptic ulcer disease, which was the basis of treatment of peptic ulcer was revolutionized by the discovery of H2-receptor antagonists, that led to the principle of acid suppression therapy for duodenal ulcer which followed decades of pref...

background: acute upper gi bleeding (ugib) is a common medical emergency situation. in the past years, important changes have taken place that might have influenced the incidence, etiology, and outcome for patients with acute ugib. the aim of this study was to determine current time trends in the incidence, management, and prognosis of patients with ugib in 14 years period in a region in center...

background: in developing countries primary antibiotic-resistance and poor compliance are the main causes of helicobacter pylori (hp) eradication failure of standard regimens. aim: to investigate eradication rate, patient's compliance and tolerability of a 1-wk azithromycin based quaruple therapy versus the 2-wk conventional therapy. materials and methods: a total of 129 hp-positive patients we...

background acute upper gastrointestinal bleeding (ugib) is a common medical emergency and is known as one of the main causes of mortality and morbidity. this research was conducted to study the causes and risk factors for ugib, in a referral center. methods in this cross sectional study, carried out in a one year period, all patients with acute ugib living in khorramabad city and surrounding ar...

background :the cag pathogenicity island includes a number of genes, including cytotoxin-associated protein a (caga) and vacuolatingcytotoxin (vaca) genotypes, which are associated with bacterial virulence. although the role of caga and vaca in the virulence of helicobacter pylori (h. pylori) is well-established in epidemiological studies, the relationship between the caga and vaca genotypes in...

BACKGROUND AND AIMS The genetic trait plays a part in the pathogenesis of peptic ulcer disease. To identify a DNA marker for peptic ulcer disease, the association between the restriction fragment length polymorphism (RFLP) of the pepsinogen C (PGC) gene and peptic ulcer disease was investigated. PATIENTS AND METHODS One hundred and seventy seven unrelated controls, 75 patients with gastric ul...

For more than a century, peptic ulcer disease has been a major cause of morbidity and mortality. In the early part of the 20th century, when stress and diet were judged to be important pathogenetic factors for peptic ulceration, patients with peptic ulcers were treated with hospitalization, bed rest, and the prescription of “bland” diets. By the 1950s, investigators and clinicians had focused t...

Wernicke’s encephalopathy is an acute neurological syndrome due to thiamine deficiency. Though classically described in relation to chronic malnutrition associated with alcoholism, it can also be precipitated in nonalcoholics due to various causes like gastrointestinal surgeries, recurrent vomiting, peptic ulcer disease, cancer chemotherapy and peritoneal or hemodialysis [1]. As the classical t...

The Development and Assessment of a Herbal Floating Tablet for Peptic Ulcer Disease. goal creating herbal floating tablet is to extend the drugs duration in gastrointestinal tract. This will increase bioavailability result greater absorption than with convectional dose form. Due its gastro-retentive feature, medicine remains at site inflammation longer amount time, resulting more targeted actio...