Critical to the success of analog synthesis in VASE is the accuracy of analog performance estimation at various levels of abstraction. The analog performance estimator (APE) in VASE is used during mixed signal partitioning, analog behavior synthesis as well as analog circuit synthesis. APE is capable of accepting the design parameters (bias current) of an analog component as input and determine...

Assembly of amyloid-beta peptide (Aβ) into cytotoxic oligomeric and fibrillar aggregates is believed to be a major pathologic event in Alzheimer's disease (AD) and interfering with Aβ aggregation is an important strategy in the development of novel therapeutic approaches. Prior studies have shown that the double N-methylated analogue of islet amyloid polypeptide (IAPP) IAPP-GI, which is a confo...