In some patients, the permanent central incisors fail to erupt and become impacted within the alveolus. In individuals with unfavorable impactions, surgical replantation may be considered to be a reasonable solution before orthodontic repositioning. In this clinical case report, a 9-year-old male patient presented with the permanent maxillary left central incisor in an inverted position high in...

PURPOSE The purpose of this study was to assess the outcomes of temporomandibular joint (TMJ) disc repositioning as a surgical treatment for TMJ internal derangement (ID). MATERIALS AND METHODS By retrospective chart review, all patients who had TMJ disc repositioning for treatment of TMJ ID from 1984 to 1990 were identified. Attempts were made to locate these patients, and they were sent a T...

SUMMARY Systematic studies of drug repositioning require the integration of multi-level drug data, including basic chemical information (such as SMILES), drug targets, target-related signaling pathways, clinical trial information and Food and Drug Administration (FDA)-approval information, to predict new potential indications of existing drugs. Currently available databases, however, lack query...

Drug repositioning helps identify new indications for marketed drugs and clinical candidates. In this study, we proposed an integrative computational framework to predict novel drug indications for both approved drugs and clinical molecules by integrating chemical, biological and phenotypic data sources. We defined different similarity measures for each of these data sources and utilized a weig...

The authors report a 64-year-old man who developed persistent direction fixed nystagmus after a canalith repositioning maneuver for horizontal canal benign paroxysmal positional vertigo (HC-BPPV). The patient was initially diagnosed with right HC-BPPV given that the Dix-Hallpike test showed geotropic horizontal nystagmus that was more pronounced on the right side, although the roll test did not...

The fangs of vipers are extremely long, rotating, hollow teeth. Analysis of video records of more than 750 strikes recorded at 60 or 250 frames per second for 285 individuals representing 86 species in 31 genera shows that vipers reposition fangs after initial contact with prey in more than a third of the strikes. Repositioning resulted when fangs missed prey entirely or hit prey regions that d...

Alzheimer's Disease (AD) is the most common cause of dementia, affecting approximately two thirds of the 35 million people worldwide with the condition. Despite this, effective treatments are lacking, and there are no drugs that elicit disease modifying effects to improve outcome. There is an urgent need to develop and evaluate more effective pharmacological treatments. Drug repositioning offer...

BACKGROUND In a segmental mandibular reconstruction with a free vascularized flap, reproducing the optimal relationship between the condyle and glenoid fossa, and maintaining correct occlusion are important. We examined the practicality of a repositioning technique that combined bone plate fixation of the infrazygomatic crest and the coronoid process (infrazygomatico-coronoid fixation [IZCF]) w...

In our work we focus on Robotic Mobile Fulfillment Systems in e-commerce distribution centers. These systems were designed to increase pick rates by employing mobile robots bringing movable storage units (so-called pods) to pick and replenishment stations as needed, and back to the storage area afterwards. One advantage of this approach is that repositioning of inventory can be done continuousl...

[Purpose] In the present study, in order to examine the differences in proprioceptive senses between children with diplegic CP and children with hemiplegic CP, neck reposition errors were measured. [Subjects and Methods] Head reposition senses were measured after neck flexion, extension, and left-right rotation, using head repositioning accuracy tests. These tests were done with 12 children wit...