Back ground: Vincristine (VCR), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. Neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids. Materials and Methods: This study was a retrospective and ...

Peripheral neuropathy is a neurological condition that commonly presents to the practicing podiatrist. Traditionally when sensory neuropathy is present one assumes diabetes mellitus to be the contributing aetiology. However, this is not always the case. Other common causes such as spinal damage, alcoholism, and vitamin B12 deficiency can be precipitating aetiologies that the clinician would be ...

A woman developed peripheral neuropathy and optic neuritis while receiving ethambutol in the retreatment of drug-resistant pulmonary tuberculosis. There was prompt improvement in peripheral neuropathy and the ocular symptoms following the withdrawal of the drug. The clinical events in this case suggest that occasionally symptoms of peripheral neuropathy may precede the development of optic neur...

Among the various etiologies of peripheral neuropathy, S. aureus is a rare cause that is not even mentioned in standard textbooks. Here we like to report three clinical scenarios where patients with different manifestations of S. aureus infection developed peripheral neuropathy presenting as quadriparesis, which subsided gradually with control of infection and supportive care. No other known ca...

In this fifth article in our ‘Test Tips’ series, Dr Katherine Bishop and Ruth Poole examine the relative benefits limitations of four commonly-used tests for diabetic peripheral neuropathy.

The idiopathic hypereosinophilic syndrome (HES) represents a leukoproliferative disorder, characterized by unexplained prolonged eosinophilia (>6 months) and evidence of specific organ damage. So far, the peripheral neuropathy associated with skin manifestations of HES has not been reported in the dermatologic literature although the incidence of peripheral neuropathy after HES ranges from 6~52...

Tests for cardiovascular function were made in 34 workers exposed to organic solvents for several years (mean 16.2 years). The results were compared with those of 52 healthy subjects. All the cardiovascular parameters were lower in the exposed group. The exposed subjects with evidence of peripheral neuropathy had lower values than those without neuropathy. The findings suggest that peripheral p...

Peripheral neuropathy represents one of the common diabetic complications in patients with diabetes mellitus type 2 (DMT2). affects feet, legs, hands, and arms. It was found that one-third to one-half diabetics have peripheral neuropathy. The current study aimed evaluate level visfatin patient groups or without comparison healthy subjects knowledge whether can be applied as a predictor factor f...

Peripheral neuropathy occurs as a component of several common and many rare diseases. It is heterogeneous in etiology, diverse in pathology, and varied in severity. Peripheral neuropathy is often overlooked, underestimated and not evaluated in day to day practice. The prevalence of neuropathy is well studied in patients with diabetes mellitus in most of the studies and other causes of neuropath...

OBJECTIVE To report the detection of mutations in the SCARB2 gene in a previously described patient with progressive myoclonus epilepsy (PME) and demyelinating peripheral neuropathy. DESIGN Case report. SETTING Epilepsy Genetics Research Laboratory and Epilepsy Service in a tertiary care center. PATIENT A 27-year old male patient with PME with preserved intellect and peripheral neuropathy...