Results 15 patients were identified. 13 were male and all of white European origin. None gave a family history of similar symptoms. Current median age is 28.3 years with median symptom duration of 15 years. 6 patients presented after the age of 16, and 5 before the age 5. 3 patients reported precipitants for their attacks, in all cases stress and fatigue. 13 patients reported regular attacks ev...

Results Individual episodes of fever usually resolved with a single intramuscular 1 mg/kg dose of methyl prednisolone. The mean fever resolve duration during the febril episode was 1.64 hours. FMF gene was investigated in 109 and we determined heterozygot MEFV gene mutations in 19 of our patients (17%). At the onset of febril episodes the mean CRP value was 6.09±8.48 mg/dl (1-38), the mean Seru...

Introduction PFAPA syndrome (acronym for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) is the most common cause of periodic fever in childhood. It is considered part of the wide family of the autoinflammatory diseases, but a genetic or molecular marker hasn’t been identified yet, therefore, its etiology is still unknown. Diagnosis is essentially based on clinical crite...

Introduction The PFAPA syndrome, associated with aphthous stomatitis, pharyngitis and cervical adenitis which is characterized by monthly flare-ups of fever is quite common in early childhood. Affected children experience their first attack before the age of 5, with fever episodes usually abating in adolescence or young adulthood. Usually a single administration of oral corticosteroids aborts a...