Drug delivery system is an amazing tool which widely used for drug protection and its controlled release in order to enhance bioavailability, reduce side effects therefore improve overall therapy. Hydrogels have been attracted great attention as carriers due their physicochemical properties, similarity the living tissues biocompatibility. One group of pH sensitive hydrogels are based on poly(me...

pH-responsive hydrogels are capable of converting chemical energy to mechanical work. To optimize their use as actuators, their response when operating against an external load must be fully characterized. Here, the actuation strain of a model pH-sensitive hydrogel as a function of different constant loads is studied. The experimental actuation strain, produced by switching the pH from 2 to 12,...

Silk fibroin hydrogels with tunable properties could be obtained from aqueous fibroin solutions (4.2 w/v %) in a short period of time. This was achieved by the addition of ethylene glycol diglycidyl ether (EGDE) into the reaction solution. Introduction of EGDE cross-links between the fibroin molecules decreases the mobility of the chains, which triggers the conformational transition from random...

Blend hydrogels composed of carboxymethyl chitosan (CMCh) and poly (acrylonitrile) (PAN) were synthesized via crosslinking method. Several analyses were made to investigate both physical and thermal properties of CMCh/PAN hydrogels like; FTIR, scanning electron microscope, XRD and thermogravimetric analysis (TGA). TGA results showed that CMCh/PAN hydrogels are thermally more stable than CMCh an...

The present study investigates some hydrogels, based on natural, biodegradable and biocompatible polysaccharides, such as cellulose (C) and chondroitin sulfate (CS), as sustained release carriers, and evaluates their biocompatibility. Investigations were performed on cellulose/chondroitin sulfate (C/CS) hydrogels, in different mixing ratios. Swelling and drug delivery studies were conducted in ...

The development of hydrogels based on natural polysaccharides was investigated by preparing mixtures of policaju/chitosan at weight ratios of 1:4 and 2:3. Utilizing dynamic light scattering (DLS) techniques for these mixtures, an increase on the hydrodynamic particle radius was observed varying their pH from 3.0 to 12.0. Furthermore, a reduction of ζ-potential was also observed for the same pH ...