Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available.

A scientific rationale is provided for estimating acceptable daily intake values (ADIs) for compounds with limited or no toxicity information to support pharmaceutical manufacturing operations. These ADIs are based on application of the "thresholds of toxicological concern" (TTC) principle, in which levels of human exposure are estimated that pose no appreciable risk to human health. The same c...

In modern times, seaweeds have become widely involved in several biotechnological applications due to the variety of their constituent bioactive compounds. The consumption dates ancient times; however, only from last few decades research can we explain mechanisms action and potential seaweed-derived compounds, which has led involvement food, cosmetic, pharmaceutical, nutraceutical industries. M...

Biotechnology has continued to advance the state of the art in pharmaceutical research and discovery, especially in the generation and screening of molecular diversity [1]. Patents have begun to issue on both chemical [2] and biological [3] strategies for creating and evaluating libraries of compounds. Whether structured or random in design, these combinatorial collections, composed of natural ...

Widespread detection of pharmaceutical compounds in water environment has been a serious concern recently, while conventional sewage treatments are ineffective for their elimination. But, advanced oxidation techniques are very promising to remove varieties of organic contaminants in water. This research aims to elucidate oxidation potentials of sixteen commonly used pharmaceutical compounds in ...

Non-technical: In collaboration with the computational chemists at Telik, we will develop and apply novel approaches of Machine Learning to the characterization and classification of organic molecules with respect to their potential as pharmaceutical agents. In preliminary research we have already shown that our methods greatly improve the efficiency of the drug discovery cycle. In particular, ...

Aims: The aims of the research were to synthesize, characterize some palmitoyl amino acids and their aromatic analogues and to screen the synthesized compounds for possible antibacterial activity Study Design: Synthesis, characterization and antibacterial screening of palmitoyl amino acids and their aromatic analogues. Place and Duration of Study: Department of Pharmaceutical and Medicinal Chem...

Ultraviolet photolysis and ultraviolet and hydrogen peroxide oxidation of fourteen commonly used pharmaceutical compounds and two personal care products in mixed solution using low pressure ultraviolet lamp was investigated in laboratory batch experiments. Removal of the compounds followed the first-order reaction kinetic. Three distinct impacts of hydrogen peroxide on ultraviolet and hydrogen ...

Fecal coliform bacteria are widely used as indicators of sewage contamination in surface water. However, there are some disadvantages in these microbial techniques including time consuming (18-48h) and inability in discriminating between human and animal fecal material sources. Therefore, it is necessary to seek a more specific indicator of human sanitary waste. In this study, the feasibility w...

In this study, the concentration probability distributions of 82 pharmaceutical compounds detected in the effluents of 179 European wastewater treatment plants were computed and inserted into a multimedia fate model. The comparative ecotoxicological impact of the direct emission of these compounds from wastewater treatment plants on freshwater ecosystems, based on a potentially affected fractio...