The interaction between Coxiella burnetii and peritoneal macrophages obtained from immune guinea pigs was studied by transmission electron microscopy. Phagocytosis and subsequent fate of ingested phase I and II rickettsiae were compared. Phase I rickettsiae were more resistant to phagocytosis than were phase II organisms. Macrophages from phase I- and II-immunized animals were equally capable o...

The conclusions from the most recent Phase II publications by Curtis et al and Gadad et al contradict those arising from Phase I. Conclusions of these Phase II papers also contradict those from earlier Phase II conference abstracts and materials as well as internal study reports. Phase I papers observed consistent significant differences in brain, behavior, learning and gastrointestinal outcome...

BACKGROUND Clinical research and drug development in orphan diseases are challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug-approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. METHODS A Bayesian m...

Author Title Number of patients Study type #4060 Heinemann et al. [1] Randomized phase II trial with an uPA inhibitor (WX-671) in patients with locally advanced nonmetastatic pancreatic cancer 95 Prospective Randomized; phase II #4058 Ioka et al. [7] A multicenter phase II trial of S-1 with concurrent radiotherapy for locally advanced pancreatic cancer 61 Prospective Single arm; phase II

a sensitive and selective solid phase extraction procedure for the determination of traces of cd(ii),zn(ii) and ag(i) ions has been developed. an alumina-sodium dodecyl sulfate (sds) coated on with2,3 di hydro 2,3 para tolyl qinazoline (1 h)- 4 one (dptqo). the influences of the analyticalparameters including ph and sample volume were investigated. common coexisting ions did notinterfere on the...

BACKGROUND Integrated phase II/III trial designs implement the phase II and phase III aspects of oncology studies into a single trial. Despite a body of literature discussing the merits of integrated phase II/III clinical trial designs within the past two decades, implementation of this design has been limited in oncology studies. PURPOSE We provide a brief discussion of the potential advanta...

Condensins I and II are multisubunit complexes that play essential yet distinct functions in chromosome condensation and segregation in mitosis. Unlike condensin I, condensin II localizes to the nucleus during interphase, but it remains poorly understood what functions condensin II might have before mitotic entry. Here, we report that condensin II changes its chromatin-binding property during S...