cause mild overtreatment, i.e., a reduction in dietary Phe allowances in excess of metabolic tolerance. This is not critical with Phe concentrations at or above the upper limit of normal. Still, neurological outcome has also been demonstrated to be adversely affected by Phe deficiency (14 ). In view of an overestimation by up to 60 mmol/L in the low concentration range and a target range of 40–...

Auxotrophic mutants of the actinomycete Amycolatopsis methanolica requiring l-Phe or l-Tyr were isolated and identified as strains lacking prephenate dehydratase (strain GH71) or arogenate dehydrogenase (strain GH70), respectively. A. methanolica thus employs single pathways only for the biosynthesis of these aromatic amino acids. Anion-exchange chromatography of extracts revealed two peaks wit...

The hydrolysis of the chromogenic peptide Pro-Thr-Glu-Phe-Phe(4-NO2)-Arg-Leu at the Phe-Phe(4-NO2) bond by nine aspartic proteinases of animal origin and seven enzymes from micro-organisms is described [Phe(4-NO2) is p-nitro-L-phenylalanine]. A further series of six peptides was synthesized in which the residue in the P3 position was systematically varied from hydrophobic to hydrophilic. The Ph...

OBJECTIVES The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs). METHODS The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed to emissions from asphalt (medium PAH exposure level, n = 26) and coke ovens ...

Patients should receive the same type of covid-19 vaccine for their first and second doses, but they could be given different brands if is not available or there no record which person received first, Public Health England (PHE) has said. Mary Ramsay, head immunisations at PHE, told The BMJ that “every effort made to give [patients] vaccine, where this possible it better a dose another …

Studies of the processes self-organization and self-assembly various complexly organized (including spiral) structures based on amino acids intensively carried out in recent years. Various methods molecular modeling, including dynamics (MD) methods, are developed. In this paper, we propose a new approach for relatively simple technique conducting MD simulation (MDS) nanostructures, determining ...

The structure and dioxygen-reactivity of copper(I) complexes R supported by N,N-bis(6-methylpyridin-2-ylmethyl)amine tridentate ligands L2R[R (N-alkyl substituent)=-CH2Ph (Bn), -CH2CH2Ph (Phe) and -CH2CHPh2(PhePh)] have been examined and compared with those of copper(I) complex (Phe) of N,N-bis[2-(pyridin-2-yl)ethyl]amine tridentate ligand L1(Phe) and copper(I) complex (Phe) of N,N-bis(pyridin-...