Recent findings report the selective internalization of core planar cell polarity components during mitosis followed by cell-non-autonomous polarized recycling. This novel mechanistic model explains how tissue polarity is inherited in daughter cells of proliferative tissue.

Juan A. López1, Enrique Sedano1, Luis Esteban2, Gabriel Caffarena3, Angel Fernández-Herrero1 and Carlos Carreras1 1Departamento de Ingeniería Electrónica, Universidad Politécnica de Madrid, 2Laboratorio Nacional de Fusión, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), 3Departamento de Ingeniería de Sistemas de Información y de Telecomunicación, Universidad CEU-...

Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; ...

These studies examined in vitro metabolism of phencyclidine (PCP) in a series of human liver microsomes (N = 10). Each sample was characterized for cytochrome P450 (CYP) content and for CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, CYP3A, CYP4A, and lauric acid 11-hydroxylation metabolic activities. At least five PCP metabolites (c-PPC, t-PPC, PCHP, an unknown metabolite, and an irreversibly bound metabol...

The history, symptoms, diagnosis and treatment of phencyclidine hydrochloride (PCP) intoxication, the pharmacology of PCP and the detection, identification and analysis of PCP are reviewed. The history of PCP from its synthesis in the early 1950s to the present is discussed. Intoxication with low to moderate doses of PCP resembles an acute, confusing state. High doses may cause serious neurolog...