In the crystal structure of the title compound, C(22)H(17)BrO(6), the quinone ring makes a dihedral angle of 81.84 (3)° with the benzene ring. The chiral C atoms, viz. the ring C atoms bearing the hydr-oxy and bromo-phenyl substituents, exhibit R and S configurations, respectively. The terminal ethyl group of the -CO(2)CH(2)CH(3) group is disordered over two sets of sites with site-occupancy fa...

In the title adamantyl derivative, C(21)H(27)N(3)OS, the terminal meth-oxy-ethyl unit is disordered over two orientations with a refined site-occupancy ratio of 0.846 (6):0.154 (6). The 1,2,4-triazole ring is statistically planar [r.m.s. deviation = 0.002 (2) Å] and the phenyl substituent is almost perpendicular to its mean plane [dihedral angle = 83.57 (11)°]. No directional inter-molecular in...

OBJECTIVE To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function. DESIGN Prospective, before-after trial. SETTING Outpatient clinic of a university clinic for otorhinolaryngology. PATIENTS A total of 20 patients with olfactory loss participated in the study. The duration of olfactory deficits ranged from 3 months to 6 years. MAIN OUTCOME MEASURE...

Previous studies have demonstrated that body position can alter auditory sensitivity. Here we demonstrate for the first time that olfactory sensitivity for the commonly used odor phenyl ethyl alcohol (PEA) (rose odor) is also dependent on body position. By using successive dilutions presented in a staircase protocol, we determined olfactory thresholds for PEA in 36 healthy participants (18 wome...

Although anaesthetic drugs are included among the aetiological factors of anosmia, limited reports exist of anosmia induced by general anaesthesia. We present the case of a 60-year-old female patient with a 3-month history of altered smell and taste immediately after recovery from general anaesthesia for a urological operation. The anaesthetic drugs used were fentanyl, propofol and sevoflurane....

Behavioral performance was examined in a task of attentional capture by luminance under conditions of ambient odors (phenyl ethyl alcohol [PEA], olfactory stimulus, and allyl isothiocyanate [AIC], mixed olfactory/trigeminal stimulus). The AIC increased the amplitude and duration of capture, whereas the presence of PEA led capture to disappear. Furthermore, the PEA caused a general slowing in th...

BACKGROUND For olfaction, several studies have reported near-infrared spectroscopy (NIRS) signal changes in the orbitofrontal cortex (OFC) during odor stimulation. However, the roles of human OFC in olfactory cognition are less well understood. This study was designed to better understand the roles of OFC for olfaction. METHODS Hemodynamic responses for phenyl ethyl alcohol or citral in the O...