Lack of Transferrin Receptor 1 in the Heart Causes Lethal Cardiomyopathy and Disruption of Mitophagy in Mice by Wenjing Xu Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Nancy C. Andrews, Supervisor ___________________________ Matthew D. Hirschey ___________________________ Deborah M. Muoio _______________________...

Molecular Regulators of Stem Cell Fate and Tumor Development in the Cerebellum by Sonja Nicole Brun Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Robert Wechsler-Reya, Co-Supervisor ___________________________ Donald McDonnell, Co-Supervisor ___________________________ Dennis Thiele ___________________________ Da...

The Role of Ral GTPases in Human Oncogenic Transformation by Sameer H. Issaq Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Christopher Counter, Supervisor ___________________________ Ann Marie Pendergast ___________________________ Christopher Nicchitta ___________________________ Christopher Kontos _____________...

Costs and Benefits of Intrasexual Aggression in Females: an Experimental Approach by Kimberly A. Rosvall Department of Biology Duke University Date:_______________________ Approved: ___________________________ Stephen Nowicki, Supervisor ___________________________ Susan Alberts ___________________________ Sonke Johnsen ___________________________ Will Wilson ___________________________ Greg Wr...

Analysis of crinkled Function in Drosophila melanogaster Hair and Bristle Morphogenesis by Vinay Singh Department of Biology Duke University Date:_______________________ Approved: ___________________________ Daniel P. Kiehart, Supervisor ___________________________ Daniel J. Lew ___________________________ Vann Bennett ___________________________ Pelin C. Volkan ___________________________ Stev...

The Role of Threshold Size in Insect Metamorphosis and Body Size Regulation by Kevin Michael Preuss Department of Biology Duke University Date:_______________________ Approved: ___________________________ H. Frederik Nijhout, Supervisor ___________________________ Daniel Kiehart ___________________________ Mohamed Noor ___________________________ John Willis ___________________________ Gregory ...

Hijacking Germ Cells for Cancer: Examining a ‘Dead End’ in Male Germ Cell Development by Matthew Simon Cook Department of Cell Biology Duke University Date:_______________________ Approved: ___________________________ Blanche Capel, Supervisor ___________________________ Sally Kornbluth ___________________________ Chris Nicchitta ___________________________ Jack Keene An abstract of a dissertat...

Leptopilina Parasitoid Wasps, Ion Channels, and Dendritic Morphology in Drosophila Nociception Paradigms by Jessica Leigh Robertson Department of Cell Biology Duke University Date:_______________________ Approved: ___________________________ W. Daniel Tracey, Supervisor ___________________________ Fan Wang ___________________________ Scott Soderling ___________________________ Wolfgang Liedtke ...

Targeting Inducible Heat Shock Protein 70 in Cancer and Dengue Virus Pathogenesis with a Novel Small Molecule Inhibitor by Matthew Keller Howe Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Timothy Haystead, Supervisor ___________________________ Stacy Horner ___________________________ Donald McDonnell __________...

Work throughout the history and philosophy of biology frequently employs 'chance', 'unpredictability', 'probability', and many similar terms. One common way of understanding how these concepts were introduced in evolution focuses on two central issues: the first use of statistical methods in evolution (Galton), and the first use of the concept of "objective chance" in evolution (Wright). I argu...