Idelalisib—a fi rst-in-class selective inhibitor of phosphoinositide-3kinase delta, which is expressed only in haemopoietic cells—has been shown to be eff ective for treatment of B-cell malignancies in two clinical trials. First, in a single-group phase 2 study, researchers enrolled 125 patients with refractory, indolent non-Hodgkin lymphoma. Idelalisib (150 mg orally, twice daily) induced an o...

phoma and NPC (17, 22), and in lymphoid cell lines derived from such tumors (4, 21). The serological association between EBV and NPC, first established by Old et al. (18), has been strengthened by Henle et al. (12) and others (3, 5, 7, 15, 16) through use of the indirect immunoflourescence test. Virtually 100% of NPC patients have detectable antibody to EBV capsid antigen in high titer (> 1:160...

Euonymus spp. (L.) are some of the most important ornamental plants. Fungal plant pathogens of ornamental plants are the most important factors causing damage. In this research two pathogenic fungal species were isolated from naturally infected Euonymus species and identified. In order to isolation of fungi from disease tissues, the obtained samples were cultured on potato dextrose agar medium....

Studies were undertaken across five field locations in Western Australia to determine the relative changes disease severity and subsequent pea yield from up four foliar pathogens associated with a complex (viz. genera Didymella, Phoma, Peronospora, Septoria) different varieties sown at three times densities. Delaying sowing of significantly (P < 0.05) reduced Ascochyta blight (all locations)...