Biatractylolide is an Atractylodes macrocephala derived bisesquiterpenoid that has been found treatment of dementia in model mice. This study aims to explore the therapeutic effect on vascular dementia. Network pharmacological techniques have used elaborate involved mechanisms biatractylolide treating Based PubChem database, Swiss target prediction and human gene database GeneCards, 19 common m...

Glutathione is an important antioxidant that plays role in myocardial remodeling. However, the exact mechanisms underlying effects of glutathione on heart failure are elusive. This study aimed to investigate treatment based network pharmacology technology. The gene expression profiles were downloaded from Gene Expression Omnibus database (GSE133054). Differentially expressed genes identified by...

Background: Geraniol has been shown to possess therapeutic or preventive effects against various types of human cancers but not affect normal physiology through regulating cell cycle and apoptosis. However, the biological geraniol on oral squamous carcinoma (OSCC) cells are unknown.
 Methods: OSCC proliferation was measured by cell-counting kit-8 colony formation assays. Cell migration ass...

The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response. The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied. This paper focuses on phosphatidylinositol 3-kinase signaling in innate and adaptive immune cells of the intestinal mucosa. The role of phosphatidylinositol 3-kinase sig...

Stimulation of the phosphatidylinositol cycle by neurotransmitters generates diacylglycerol, an activator of protein kinase C, which may regulate some forms of neurotransmission. Phorbol esters, potent inflammatory and tumor-promoting compounds, also activate protein kinase C. We demonstrate potent and selective effects of phorbol esters on smooth muscle, indicating a role for protein kinase C ...

The stimulation of glucose transport is one of the early cellular responses to growth factors and is essential for cell proliferation, yet the molecular processes that underlie this response are poorly defined. The aim of this study was to characterize the role of the low-molecular-mass G-proteins, Ras and Rho, and their downstream targets, Raf protein kinase and phosphatidylinositol 3-kinase, ...

Activation of endothelial nitric-oxide synthase (eNOS) has been shown to occur through various pathways involving increases in the cytosolic Ca(2+) concentration, activation of the phosphatidylinositol-3' kinase/Akt pathway, as well as regulation by other kinases and by protein-protein interactions. We have recently reported that eNOS, expressed in an inducible HeLa Tet-off cell line, is activa...

The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and phosphorylation of several proteins involved in the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. As controls, adult pre...

We investigated the involvement of angiotensin II and phosphatidylinositol 3-kinase in the enhanced aortic contractile responses induced by the hyperinsulinemia present in chronic insulin-treated type 1 diabetic rats. Plasma angiotensin II levels were elevated in untreated diabetic rats (versus controls), and further increased in insulin-treated diabetics. Aortic contractile responses and systo...