A series of protected beta2-dehydroamino acids has been prepared in three steps from commercially available starting materials in good yields. These were used as substrates in rhodium-catalyzed asymmetric hydrogenation applying a mixed ligand system of monodentate phosphoramidites and phosphines. Optimization of the catalyst structure was achieved by high throughput experimentation. High enanti...

Competent partners: π-Allyl–nickel precatalysts supported by dialkylterphenyl phosphines efficiently couple a wide range of electrophiles including aryl iodides/bromides/chlorides and, for the first time, and alkenyl tosylates with aromatic aliphatic thiols. In addition, tandem C−S C−N coupling multi-electrophile/nucleophile combinations is achieved in completely chemoselective manner leading t...

Despite the well-established pharmacological properties of aromatic sulfonamides and interest introducing ferrocene into drugs, have scarcely been studied. General synthetic methods using lithium bases to perform sulfonamide-directed deprotolithiation or “halogen dance” reaction are here reported for functionalization N,N-dialkylferrocenesulfonamides toward various polysubstituted derivatives. ...

The phosphorus stereocentre, present in a diversity of compounds ranging from phosphonates to phosphines, plays crucial role various fields, particular catalysis, materials science, agrochemistry and drug development. unique structural stereochemical features intrinsically homochiral units form the incentive for major current efforts towards developing stereoselective synthesis methodology P-ch...

A photoinduced reaction between TMDPO (diphenyl(2,4,6-trimethylbenzoyl)-phosphine oxide) and perfluoroalkyl iodides successfully affords P-(perfluoroalkyl)diphenylphosphines as promising ligands for recyclable catalysts. Interestingly, the perfluoroalkylation reaction involves the reduction of phosphorus(V) compounds to phosphorus(III) species. The advantages of the present reaction include the...

The synthesis and structural characterization of a series of tripodal tris(phosphine) ligands, containing SiMe2 elbow groups, is described. The significant steric congestion in these ligands, due to the silylmethyl substituents, is manifest both in the solid-state structures and in the solution NMR spectra of the free ligands. Variable temperature 1H{31P} NMR studies of one of the ligands, CH3C...

Phosphine has been known to science since the birth of modern chemistry. WHO reports that the technical product usually has a foul odour, like "fishy" or "garlicky" because of the presence of substituted phosphines and diphosphine (P2H4). Many medico-legal autopsy cases have been reported positive for aluminium phosphide even though there was neither any suspicion of consuming aluminium phosphi...

The evolution of olefin metathesis into a reaction routinely used to form new carbon–carbon double bonds has been enabled by the development of well-defined transition-metal catalysts. [1,2] Many metathesis catalysts based on the [L2X2Ru=CHR] scaffold have been synthesized in an effort to increase catalyst stability, activity, and substrate scope.[3–10] A significant gain in these areas was ach...