Background: The role of vezatin in epilepsy remains unknown. Therefore, the aim present study was to investigate underlying roles epilepsy. Methods: expression pattern vivo and vitro investigated by immunofluorescence western blotting. Pilocarpine (PILO)-induced epileptic mice were subjected behavioral tests determine regulating seizure activity. Whole-cell patch-clamp recordings obtained vi...

clinical differential diagnosisthe organic acidemias are important in the differential diagnosis of metabolic and neurologic derangement in the neonate and of new-onset neurologic signs in the older child. a-organic aciduriaseveral disorders, not classified as primary disorders of organic acid metabolism, have a characteristic urinary organic acid profile that suggests the appropriate diagnosis...

Abstract MCP-1–induced monocyte chemotaxis is a crucial event in inflammation and atherogenesis. Identifying the important signal transduction pathways that control can unravel potential targets for preventive therapies inflammatory disease conditions. Previous studies have shown focal adhesion kinase Pyk2 plays critical role motility. In this study, we investigated MCP-1–mediated activation of...

ABSTRACT Animal steroid hormones initiate signaling by passive diffusion into cells and binding to their nuclear receptors regulate gene expression. can via G protein-coupled (GPCRs); however, the underlying mechanisms are unclear. Here, we show that a newly discovered ecdysone-responsive GPCR, ErGPCR-3, transmits hormone 20-hydroxyecdysone (20E) signal 20E promoting its entry in lepidopteran i...

Front Cover: The cover image is based on the Research Article Proper phosphorylation of septin 12 regulates 4 and soluble adenylyl cyclase expression to induce sperm capacitation by Han-Yu Wang et al., https://doi.org/10.1002/jcp.30951.

Objective(s): This study aimed to investigate the effect of aerobic training on serum levels of Klotho, cardiac tissue levels of H2O2 and phosphorylation of ERK1/2 and P38 as well as left ventricular internal diameter (LVID), the left ventricle wall thickness (LVWT) and fibrosis in middle-aged rats. Materials and Methods: Forty wistar rats, including young rats (n=10, 4 month-old) and middle-ag...

Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of cinnamaldehyde on met...