The archaeological record of the Pleistocene/Holocene transition (PHT) demonstrates that the technology and mobility of Prearchaic hunter-gatherers differed dramatically from later Holocene foragers, suggesting a hunting-oriented subsistence. However, meager PHT faunal assemblages imply a generalized, broad-spectrum diet. Ethnographic analogy fails to provide a behavioral framework for understa...

Neurovascular responses to mental stress have been linked to several cardiovascular diseases, including hypertension. Mean arterial pressure (MAP), muscle sympathetic nerve activity (MSNA), and forearm vascular responses to mental stress are well documented in normotensive (NT) subjects, but responses in prehypertensive (PHT) subjects remain unclear. We tested the hypothesis that PHT would elic...

INTRODUCTION Pulmonary hypertension (PHT) associated with systemic lupus erythematosus (SLE) has a grave prognosis. Continuous prostacyclin infusion significantly reduces pulmonary arterial pressure (PAP) and may improve survival in patients with primary and secondary PHT. We report our experience with intermittent epoprostenol (EPO) infusion in SLE patients with PHT. CLINICAL CHARACTERISTICS...

This paper presents a novel methodology for approximating the queue length (the number of customers in the system) distributions of time-varying non-Markovian manyserver queues (e.g., Gt/Gt/nt queues), where the number of servers (nt) is large. Our methodology consists of two steps. The first step uses phase-type distributions to approximate the general inter-arrival and service times, thus gen...

Phenytoin (PHT) and Valproate (VPA) are known to induce cognitive dysfunction, in terms of long term memory loss. Nitric oxide (NO) on the other hand is said to help in long term potentiation and hence enhance memory. The effects of nitric oxide donor L-arginine (L-Arg) and nitric oxide synthase inhibitor N-W-L-Nitroarginine (L-NOARG) were studied on the cognitive dysfunction, induced by PHT an...

Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to pharmacoresistance that occurs in a subset of epileptic patients. Whether P-gp expression and function is affected in other brain regions and in organs that are involved in drug metabolism is less studi...

W develop a numerically exact method for evaluating the time-dependent mean, variance, and higherorder moments of the number of entities in a Pht/Pht/ queueing system. We also develop a numerically exact method for evaluating the distribution function and moments of the virtual sojourn time for any time t; in our setting, the virtual sojourn time is equivalent to the service time for virtual en...

Pulmonary hypertension (PHT) is an important complication of systemic sclerosis (SSc). Echocardiography can be used to detect PHT and, with Doppler echocardiography, the pulmonary arterial systolic pressure (PASP) can often be estimated. We have undertaken a study to compare echocardiographic assessment with right heart catheterization (RHC) in 33 SSc patients in whom clinical assessment [inclu...

Antiepileptic drugs-induced Stevens-Johnson syndrome (SJS) is a life-threatening severe cutaneous adverse reaction. Recent studies in Thailand and Taiwan showed a significant association between phenytoin (PHT)-induced SJS and human leucocyte antigen HLA-B*1502 allele. Although the US FDA had issued an alert to clinicians, insufficient information is available to recommend testing for HLA-B*150...