This paper develops an informative column generation and decomposition method for a capacitated multi-item lot sizing and facility location problem with backlogging. The method hybridizes column generation to achieve a relaxed linear solution and a decomposition method (i.e., relax-and-fix) to achieve a feasible solution. The two solutions are used for a neighborhood search procedure that fixes...

Disordered parental attachment can commit children to lives characterised by relationship difficulties, behaviour problems, educational failure, and poor self-esteem. It is a major root of trans-generational neglect and abuse and frequently underlies mental health problems, drug and alcohol addiction, homelessness, and crime. Early childhood setting of hypothalamus-pituitary-adrenal axis functi...

Im Mai 2008 fand die Jahrestagung der Fachgruppe Software-Architektur in Augsburg statt. Die Fachgruppe entstand im Jahre 2006 aus dem gleichnamigen Arbeitskreis und bildet seitdem eine deutschsprachige Plattform für den Austausch von Erfahrungen und die Diskussion neuer Ansätze auf dem Gebiet der Software-Architektur. Der Austausch von Erfahrungen und die Diskussion aktueller Entwicklungen sta...

Cell adhesion is mediated by numerous membrane receptors. It is desirable to derive the outcome of a cell-surface encounter from the molecular properties of interacting receptors and ligands. However, conventional parameters such as affinity or kinetic constants are often insufficient to account for receptor efficiency. Avidity is a qualitative concept frequently used to describe biomolecule in...

In most countries there are meaningful issues over which politicians and voters take varying positions. Countless scholarly approaches to understanding political or voting behavior engage such policy preferences as a salient political cleavage, the most common of which places political actors on a left-right spectrum defined by opposing views on the role of government or the notions of liberal ...

In Norway, the management of natural and cultural resources is subject to increasing public scrutiny. Con icts are escalating over many issues concerning the balance between preservation and utilisation . Traditionally con icts over issues like growth in commercial nature tourism, predator control, forest policies, protected areas management, cultural heritage protection , and rights associat...