Flagellar class 3 operons of Escherichia coli and Salmonella are transcribed by RNA polymerase containing sigma 28. The consensus sequence of the sigma 28-dependent promoters was believed to be TAAA N15 GCCGATAA. In this study, we found that the E. coli genome contains a large number of sequences homologous to this consensus. However, we showed that they do not always exert a sigma 28-dependent...

A number of recent studies examining historical experiences with deflation have called into question the widely-held view that maintains deflation is economically harmful. These studies contend that a broad, historical perspective reveals a more nuanced view of deflation, one that requires taking seriously both malign and benign deflation. This paper builds on these findings by taking an in-dep...

The need for antineoplastic compounds with novel mechanisms of action is great. One such agent is the recently synthesized polyamine analogue N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane (CPENSpm). Exposure of hormone-dependent and -independent human breast cancer cells to 0.1-10 microM CPENSpm led to both growth inhibition and induction of programmed cell death. Fragmentation of DNA to...

Information theory has long pointed to the promise of physical layer cooperation in boosting the spectral efficiency of wireless networks. Yet, the optimum relaying strategy to achieve the network capacity has till date remained elusive. Recently however, a relaying strategy termed Quantize-Map-and-Forward (QMF) was proved to achieve the capacity of arbitrary wireless networks within a bounded ...

This article presents an overview of current concepts of evidence-based diagnosis using a variety of imaging modalities for a broad spectrum of musculoskeletal conditions and syndromes. There is limited but increasing evidence that physical therapists appropriately use diagnostic studies in clinical practice. Pathology revealed by diagnostic studies must be viewed in the context of the complete...

The purpose of this article is to discuss the theoretical concept of moral distress in the context of current physical therapy practice and ethics knowledge and differentiate it from emotional distress and burnout. Moral distress, largely discussed in nursing, is a theoretical concept that has the potential to elucidate the experiences of physical therapists delivering direct care to patients i...

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We are excited to introduce 2 special issues in the Journal that feature articles relevant to direct access physical therapist practice. The rationale for covering these topics in the physical therapy literature is clear: the American Physical Therapy Association’s (APTA’s) Vision 2020 states that, ‘‘By 2020, physical therapy will be provided by physical therapists who are doctors of physical t...