Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous media and low oral bioavailability in pre-clinical species from the solid dosage form. The strategy of introducing polar hydroxymethyl groups has ...

The purpose of this study was to evaluate the hydrogenionic potential and electrical conductivity of Portland cements and MTA, as well as the amount of arsenic and calcium released from these materials. In Teflon molds, samples of each material were agitated and added to plastic flasks containing distilled water for 3, 24, 72 and 168 h. The results were analyzed with a Kruskal-Wallis non-parame...

Lactoperoxidase (LP) is one of the most prominent enzymes in bovine milk and catalyses the inactivation of a wide range of micro-organisms in the lactoperoxidase system (LP-s). LP-systems are also identified as natural antimicrobial systems in human secretions such as saliva, tear-fluid and milk and are found to be harmless to mammalian cells. The detailed molecular structure of LP is identifie...

Luís C. Branco1, Gonçalo V.S.M. Carrera1, João Aires-de-Sousa1, Ignacio Lopez Martin2, Raquel Frade3 and Carlos A.M. Afonso3 1REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica 2Departamento de Química Orgánica, Universidad de Extremadura, Cáceres E-10071, 3CQFM, Centro de Química-Física Molecular, IN Institu...

Ahstraet--Hydrotalcite solid solutions were prepared by coprecipitation followed by hydrothermal treatment between 150 ~ and 250~C. Based on the structural formula [Mgl_xAlx(OH)~lX+l(COz)x/2 9 mH20] x-, pure solid solutions were formed in the range Al/(Al + Mg) = 0.2 to 0.33, where m = (1 3x/2). Maximum crystallite size was achieved by hydrothermal treatment between 180 ~ and 200~ with x = 0.33...

Background: Many of the most common cancers, such as prostate and breast cancer are due to the presence of harmful agents and compounds in processed foods, including nitrite. In this research the physicochemical, antioxidant, and color properties of sodium nitrite-free sausages containing different concentrations of cochineal pigment alone or in combination with cumin essential oil were studied...

There is a critical need to automatically extract and synthesize knowledge and trends in nanotechnology research from an exponentially increasing body of literature. Engineered nanomaterials (ENMs), such as nanomedicines, are continuously being discovered and Natural Language Processing approaches can semi‐automate the cataloging of ENMs and their unique physico‐chemical properties; automatical...

Sanliurfa limestone is becoming increasingly popular for both interior and exterior building applications in the local area in south east Turkey, being easy to cut and shape and suitable for many purposes. Although these limestones are low cost construction materials, they are not widely used elsewhere due to the lack of data regarding their chemical, physico-thermal and mechanical properties a...

Introduction There is now much information associating desirable and undesirable actions with chemical structure and constitution and physical properties. Hundreds of thousands of natural and synthesized compounds have been subjected to bacterial, animal and human toxicological studies and the information has been stored by computer and can be retrieved as an aid to literature search when embar...