BACKGROUND Lung adenocarcinoma is the most common subtype of Non small cell lung cancer in which the PI3K/Akt cascade is frequently deregulated. The ubiquitous expression of the PI3K and the frequent inactivation of PTEN accounts for the prolonged survival, evasion of apoptosis and metastasis in cancer. This has led to the development of PI3K inhibitors in the treatment of cancer. Synthetic PI3...

BACKGROUND Hopea Odorata, locally known as Telsur (Bangladesh), has some traditional uses as folk medicine. This study aims to investigate the antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of H. odorata leaf extracts as new therapeutic prospects predicting the activity of some of the isolated compounds of this plant. METHODS Leaves of Hopea odorata was extracted with pu...

This research aimed to explore the antioxidant potency of leaf extracts Syringodium isoetifolium seagrass. In this study, seagrass leaves were collected from local tribe’s source, dried and extracted with water, alcohol, hydro alcohols, acetone n-hexane. Phytochemical investigation on was performed using chemical gas chromatography-mass spectrometric techniques. It reveals that are enriched pha...

Background. Eryngium foetidum L. grows in the wet zone of Sri Lanka. Despite fact that this plant is widely used for healthcare purposes and as a culinary spice tropical regions, limited scientific research has been available. This study aimed to investigate phytoconstituents, essential oil (EO), antioxidative potential (AP), proximate composition, well find suitable extracting solvent extract ...

Salacia oblonga Wall containing vital phytoconstituents viz. mangiferin, salacinol, kotanolol etc has been in used since long in the treatment of diabetes, inflammation and burn wounds. The antimicrobial activity of S. oblonga aerial and root parts has been tested against drug resistant pathogens staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. Ethyl acetate extracts of ...

In the present study, the 50% hydro ethanolic extract of different varieties of spp.) peel such as Nendran (Musa spp. Pachanadan AAA) was evaluated for membrane stabilization and proteinase inhibitory activity was assessed at a concentration of 0.1g/ml for all the varieties. The standards used in this study include aspirin and diclofenac sodium. Of the four var albumin denaturation (63.42%) and...

Phytochemical investigation of the methanolic extract of the roots of Albizzia lebbeck Benth. (Fabaceae) led to the isolation of one new fatty acid ester 2' αhydroxy octyl hexadecanoate (hydroxyoctyl palmitate) and two new phenolic acid glucosidic ester characterized as salicylic acid-2-O–β-D-glucofuranosyl-6'-octadec-9"-enoate (salicylic acid arabinosyl oleate) along with a fatty acid phytocon...

There is an increasing demand for herbal medicines, health products, pharmaceuticals. Glycyrrhiza glabra Linn is a plant used in traditional medicine across the world for its ethnopharmacological value. It is found to contain important phytoconstituents such as glycyrrhizin, glycyrrhizinic acid, glabrin A and B and isoflavones. It is effectively used as anti-inflammatory, anti-bacterial, anti-f...