Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to a single immunodominant peptide of the immunizing Ag, which does not resemble the autoreactive T cells in RA. An exception is pristane-induced arthritis (PI...

PURPOSE To characterize the gadopentetate dimeglumine-enhanced MR features of recurrent medulloblastoma. METHODS The postsurgical gadopentetate dimeglumine-enhanced MR images of 48 patients (206 head examinations) with prior resection of medulloblastoma were retrospectively evaluated for enhancement in the brain parenchyma, meninges (dura, pia-arachnoid), and ventricles. RESULTS Nineteen pa...

Privacy-aware software development is gaining more and more importance for nearly all information systems that are developed nowadays. As a tool to force organizations and companies to consider privacy properly during the planning and the execution of their projects, some governments advise to perform privacy impact assessments (PIAs). During a PIA, a report has to be created that summarizes th...

Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in A...

The relaxing effects of adenosine, N-[(R)-1-methyl-2 phenylethyl]-adenosine (R-PIA) and 5-N-ethylcarboxamide adenosine (NECA) were investigated in human uterine arteries precontracted by phenylephrine in vitro. Adenosine, R-PIA and NECA relaxed isolated uterine arteries with intact endothelium, the potency order was NECA > R-PIA > adenosine. When tested on vessels devoid of their endothelium, t...

Based on pristane-induced arthritis (PIA), we found that T cells mediate TLR3 overexpression in fibroblast-like synoviocytes (FLS). The aim of this study is to determine key factors by which T cells induce TLR3 expression. Rat FLS were co-cultured with pristane primed T cell conditioned medium (PPT medium), and TLR3 expression of FLS was significantly induced. TNF-α, IFN-γ and IL-17 were domina...

Pressure-induced amorphization (PIA) and thermal-driven recrystallization have been observed in many crystalline materials. However, controllable switching between PIA and a metastable phase has not been described yet, due to the challenge to establish feasible switching methods to control the pressure and temperature precisely. Here, we demonstrate a reversible switching between PIA and therma...

Even when human point forecasts are less accurate than data-based algorithm predictions, they can still help boost performance by being used as inputs. Assuming one uses judgment indirectly in this manner, we propose changing the elicitation question from traditional direct forecast (DF) to what call private information adjustment (PIA): how much thinks should adjust its account for has that is...

Cells maintain control of their volume by the passage of KCI and water across their membranes, but the regulatory proteins are unknown. Expression in Xenopus oocytes of a novel protein, plan, activated a chloride conductance. We have cloned analogs of pIa. from rat heart and Xenopus ovary. pIa. was ldentified as an abundant soluble cytosolic protein (40 kd) that does not immunolocalize with the...