Single crystals of the title compound, [Co(C(6)H(4)NO(2))(C(18)H(27)N(6)P)]NO(3), were obtained from the reaction of nitrato[tris-(2-isopropyl-imidazol-4-yl)phosphane]cobalt(II) nitrate with picolinic acid in the presence of potassium tert-butoxide as base. The coordination polyhedron around the central Co(II) ion is about halfway between square-pyramidal and trigonal-bipyramidal geometry. In t...

A series of polynuclear metal-oxo clusters have been constructed from the dynamic polyoxometalate (POM) building block {B-α-Sb(III)W9O33} and lanthanide (Ln) linkers via a stepwise synthetic strategy with the molecular formulas of [Ln2(H2O)4{WO2(pic)}2(SbW8O30)2](10-) (Na4Li6[La-1]·28H2O, Na3Li7[Pr-2]·30H2O) and [{Ln(H2O)}{Ln(pic)}(Sb3O4)(SbW8O31)(SbW10O35)]2(24-) (K2Na6Li16[Tb-3]·63H2O, Na9Li1...

O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods ...

The title compound, C(29)H(35)N(3)O(4), was obtained by the reaction of (2S,4S,5S)-tert-butyl N-(4-amino-1-benzyl-3-hydr-oxy-5-phenyl-pent-yl)carbamate and picolinic acid using oxalyl chloride as a chlorinating reagent to activate the carboxyl group. In the crystal structure there are two mol-ecules in the asymmetric unit, which are aligned edge-to-face. In one mol-ecule, the pyridyl ring forms...

In Paper I (1) it was reported that the amount of the liver enzyme, picolinic carboxylase, is greatly increased in diabetic rats, while other related enzymes are not changed greatly. In this paper some of the factors that influence the level of this enzyme in rat liver are described. A major role was found for adrenal steroids, which are required for the increase to occur. The increase in enzym...